Kostorz-Nosal Sabina, Jastrzębski Dariusz, Kubicki Piotr, Galle Dagmara, Gałeczka-Turkiewicz Alicja, Toczylowska Beata, Ziora Dariusz
Department of Lung Diseases and Tuberculosis, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-032 Katowice, Poland.
Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 02-109 Warsaw, Poland.
J Clin Med. 2022 Jun 24;11(13):3657. doi: 10.3390/jcm11133657.
(1) Background: Pulmonary rehabilitation (PR) plays a significant therapeutic role for patients with idiopathic interstitial pneumonia (IIP). The study assessed the impact of physical activity on lung function measured by forced oscillation technique (FOT). (2) Methods: The study involved 48 patients with IIP subjected to a 3-week inpatient PR. The control group included IIP patients (n = 44) on a 3-week interval without PR. All patients were assessed at baseline and after 3 weeks of PR by FOT, spirometry, plethysmography, grip strength measurement and the 6-minute walk test. (3) Results: There were no significant changes in FOT measurements in the PR group, except for reduced reactance at 11 Hz, observed in both groups (p < 0.05). Patients who completed PR significantly improved their 6-min walk distance (6MWD) and forced vital capacity (FVC). The change in 6MWD was better in patients with higher baseline reactance (p = 0.045). (4) Conclusions: Patients with IIP benefit from PR by an increased FVC and 6MWD; however, no improvement in FOT values was noticed. Slow disease progression was observed in the study and control groups, as measured by reduced reactance at 11 Hz. Patients with lower baseline reactance limitations achieve better 6MWD improvement.
(1) 背景：肺康复（PR）对特发性间质性肺炎（IIP）患者具有重要的治疗作用。本研究评估了体力活动对通过强迫振荡技术（FOT）测量的肺功能的影响。(2) 方法：本研究纳入了48例接受为期3周住院肺康复治疗的IIP患者。对照组包括44例未接受肺康复治疗、为期3周的IIP患者。所有患者在基线时以及肺康复治疗3周后均通过FOT、肺量计、体积描记法、握力测量和6分钟步行试验进行评估。(3) 结果：肺康复治疗组的FOT测量值无显著变化，但两组均观察到11Hz时的电抗降低（p < 0.05）。完成肺康复治疗的患者6分钟步行距离（6MWD）和用力肺活量（FVC）显著改善。基线电抗较高的患者6MWD的变化更好（p = 0.045）。(4) 结论：IIP患者通过增加FVC和6MWD从肺康复治疗中获益；然而，未观察到FOT值的改善。通过11Hz时电抗降低来衡量，研究组和对照组均观察到疾病进展缓慢。基线电抗限制较低的患者6MWD改善更好。
