Hanks G W, Twycross R G, Bliss J M
Churchill Hospital, Headington, Oxford.
Anaesthesia. 1987 Aug;42(8):840-4. doi: 10.1111/j.1365-2044.1987.tb04107.x.
Eighteen of 27 patients with pain due to advanced cancer, completed a randomised crossover comparison of 4-hourly aqueous morphine sulphate and twice daily controlled release morphine tablets. There was no difference between the two regimens in analgesic efficacy or adverse effects, but there was an apparent improvement in quality of sleep on the controlled release tablets. After completion of the study, 17 patients continued with the latter medication for periods that ranged from 2 days to 94 weeks (median 6.5 weeks). Controlled release morphine tablets given twice daily provide a simpler and more convenient treatment regimen than a 4-hourly opioid for patients with cancer pain, once they have been stabilised.
27名因晚期癌症而疼痛的患者中，有18名完成了每4小时静脉注射硫酸吗啡与每日两次服用控释吗啡片的随机交叉对照试验。两种治疗方案在镇痛效果或不良反应方面并无差异，但服用控释吗啡片时睡眠质量有明显改善。研究结束后，17名患者继续服用后一种药物，持续时间从2天至94周不等（中位数为6.5周）。对于癌症疼痛患者，一旦病情稳定，每日两次服用控释吗啡片比每4小时服用一次阿片类药物提供了一种更简单、更方便的治疗方案。
