癌症疼痛的对照临床试验。它们应该如何进行对照？一项定性系统评价。
Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review.
作者信息
Bell R F, Wisløff T, Eccleston C, Kalso E
机构信息
Regional Centre of Excellence in Palliative Care Western Norway/Institute for Surgical Sciences/Pain Clinic Haukeland University Hospital, N-5021 Bergen, Norway.
出版信息
Br J Cancer. 2006 Jun 5;94(11):1559-67. doi: 10.1038/sj.bjc.6603162.
Abstract
This qualitative systematic review of the clinical methodology used in randomised, controlled trials of oral opioids (morphine, hydromorphone, oxycodone) for cancer pain underlines the difficulties of good pain research in palliative care. The current literature lacks placebo-controlled superiority trials. Recommendations for future research are discussed.
摘要
这项针对口服阿片类药物（吗啡、氢吗啡酮、羟考酮）用于癌症疼痛的随机对照试验中所采用临床方法的定性系统评价，突显了姑息治疗中高质量疼痛研究的困难。当前文献缺乏安慰剂对照的优效性试验。文中讨论了对未来研究的建议。
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