Jager S, Kremer J
Department of Obstetrics and Gynaecology, University Hospital, Groningen, Netherlands.
Ann Biol Clin (Paris). 1987;45(3):340-5.
Some immunological aspects of male infertility are discussed, including the mechanism of induction of auto-antibodies to sperm-specific antigens. Tests to determine antispermatozoal antibodies in serum are discussed. Since there is no direct relation with infertility, more attention is focused on the presence of antispermatozoal antibodies in semen. These antibodies affect male fertility by reducing the capacity of the spermatozoa to penetrate cervical mucus. This penetration inhibition is caused by autoagglutination of the spermatozoa in the ejaculate and by the shaking phenomenon. The sperm-cervical mucus contact test, based on the shaking phenomenon is described. The use of the Mixed Antiglobulin Reaction tests, to detect IgG and IgA antibodies on spermatozoa is discussed. Finally, the effect of antispermatozoal antibodies on the fertilization process is reviewed.
本文讨论了男性不育的一些免疫学方面，包括诱导精子特异性抗原自身抗体的机制。还讨论了测定血清中抗精子抗体的检测方法。由于血清抗精子抗体与不育无直接关系，因此更多的注意力集中在精液中抗精子抗体的存在上。这些抗体通过降低精子穿透宫颈黏液的能力来影响男性生育能力。这种穿透抑制是由射精中精子的自身凝集和摇动现象引起的。本文描述了基于摇动现象的精子-宫颈黏液接触试验。还讨论了使用混合抗球蛋白反应试验来检测精子上的IgG和IgA抗体。最后，综述了抗精子抗体对受精过程的影响。
