Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran.
IUBMB Life. 2020 Dec;72(12):2572-2583. doi: 10.1002/iub.2399. Epub 2020 Oct 27.
Pregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived from Curcuma longa, is mainly known by its anti-inflammatory and antioxidant properties. There are in vitro and in vivo reports revealing the preventive and ameliorating effects of curcumin against pregnancy complications. Here, we aimed to seek mechanisms underlying the modulatory effects of curcumin on dysregulated inflammatory and oxidative responses in various pregnancy complications.
妊娠并发症包括子痫前期、早产、宫内生长受限和妊娠期糖尿病，是主要的不良生殖结局。过度的炎症和氧化应激在妊娠疾病的发病机制中起着关键作用。姜黄素是姜黄的主要多酚化合物，主要以其抗炎和抗氧化特性而闻名。有体外和体内报告显示姜黄素对妊娠并发症具有预防和改善作用。在这里，我们旨在寻找姜黄素对各种妊娠并发症中失调的炎症和氧化反应的调节作用的机制。
