Tossetta Giovanni, Fantone Sonia, Giannubilo Stefano Raffaele, Marzioni Daniela
Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy.
Clinic of Obstetrics and Gynaecology, Department of Clinical Sciences, Università Politecnica delle Marche, Salesi Hospital, Azienda Ospedaliero Universitaria, 60126 Ancona, Italy.
Antioxidants (Basel). 2021 Jan 17;10(1):126. doi: 10.3390/antiox10010126.
Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of . This plant showed many beneficial effects and has been used since ancient times for both food and pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption in the human diet has become very common thanks also to the fact that this natural compound is considered quite safe as it does not have serious side effects. Its functions as an anti-inflammatory, anti-oxidant, neuroprotective, immunomodulatory, anti-toxicant, anti-apoptotic, and anti-diabetic compound are already known and widely demonstrated. There are numerous studies concerning its effects on various human pathologies including cancer, diabetes and arthritis while the studies on curcumin during pregnancy have been performed only in animal models. Data concerning the role of curcumin as anti-inflammatory compound suggest a possible use of curcumin in managing pregnancy complications such as Preeclampsia (PE), Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), PreTerm Birth (PTB), and exposure to toxic agents and pathogens. The aim of this review is to present data to support the possible use of curcumin in clinical trials on human gestation complications.
姜黄素，又称双阿魏酰甲烷，是姜黄根茎中存在的主要多酚类物质。这种植物显示出许多有益作用，自古以来就被用于食品和制药目的。由于其具有多种功能，姜黄素在人类饮食中的消费变得非常普遍，这也得益于这种天然化合物被认为相当安全，因为它没有严重的副作用。它作为抗炎、抗氧化、神经保护、免疫调节、抗毒、抗凋亡和抗糖尿病化合物的功能已经为人所知并得到广泛证实。有许多关于其对包括癌症、糖尿病和关节炎在内的各种人类疾病影响的研究，而关于孕期姜黄素的研究仅在动物模型中进行。有关姜黄素作为抗炎化合物作用的数据表明，姜黄素可能用于管理诸如子痫前期（PE）、妊娠期糖尿病（GDM）、胎儿生长受限（FGR）、早产（PTB）以及接触有毒物质和病原体等妊娠并发症。本综述的目的是提供数据，以支持姜黄素在人类妊娠并发症临床试验中的可能应用。
