Koeffler H P
Department of Medicine, UCLA School of Medicine.
Ann Intern Med. 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748.
The marriage of cytogenetics and molecular biology has resulted in major advances in our understanding of acute nonlymphocytic leukemia. These technologies reveal a number of clearly recognizable syndromes of acute nonlymphocytic leukemia. This review describes the salient features of several of these syndromes: acute myelomonocytic leukemia with abnormal eosinophils; acute nonlymphocytic leukemia with 11q abnormalities [biphenotypic leukemia with t(4;11); and acute monocytic leukemia with t(9;11)]; acute nonlymphocytic leukemia with t(8;21); acute promyelocytic leukemia; acute nonlymphocytic leukemia with normal or elevated platelet counts and rearranged 3q21 and 3q26; and acute nonlymphocytic leukemia with increased basophils and t(6;9). The pathogenesis of therapy-related leukemias is discussed also.
细胞遗传学与分子生物学的结合使我们对急性非淋巴细胞白血病的认识取得了重大进展。这些技术揭示了一些急性非淋巴细胞白血病明显可识别的综合征。本综述描述了其中几种综合征的显著特征：伴有异常嗜酸性粒细胞的急性粒单核细胞白血病；伴有11q异常的急性非淋巴细胞白血病[伴有t(4;11)的双表型白血病；以及伴有t(9;11)的急性单核细胞白血病]；伴有t(8;21)的急性非淋巴细胞白血病；急性早幼粒细胞白血病；血小板计数正常或升高且3q21和3q26重排的急性非淋巴细胞白血病；以及伴有嗜碱性粒细胞增多和t(6;9)的急性非淋巴细胞白血病。还讨论了治疗相关白血病的发病机制。
