Pedersen-Bjergaard J, Philip P
Leuk Res. 1987;11(4):315-8. doi: 10.1016/0145-2126(87)90174-3.
Most cases of therapy-related acute nonlymphocytic leukemia or preleukemia show chromosome aberrations, primarily loss of whole chromosomes No. 5 and/or No. 7 or the long arms of these two chromosomes. Other abnormalities involve chromosome No. 21, often rearranged at band 21q22, and chromosome No. 17, in some cases rearranged at band 17p13. Important cellular genes have recently been localized to these regions, including the gene for one hematopoietic growth factor and the gene for the receptor for another hematopoietic growth factor. It is suggested that the total loss or change of structure or expression of some of these genes resulting from the various chromosome aberrations may be of pathogenetic significance in therapy-related acute nonlymphocytic leukemia.
大多数与治疗相关的急性非淋巴细胞白血病或白血病前期病例显示出染色体畸变，主要是整条5号和/或7号染色体缺失，或这两条染色体的长臂缺失。其他异常涉及21号染色体，常在21q22带发生重排，以及17号染色体，在某些情况下在17p13带发生重排。最近重要的细胞基因已定位到这些区域，包括一种造血生长因子的基因和另一种造血生长因子受体的基因。有人提出，由各种染色体畸变导致的这些基因中的一些基因的完全缺失、结构改变或表达改变，可能在与治疗相关的急性非淋巴细胞白血病中具有致病意义。
