Yagil E, Be'eri H
Mol Gen Genet. 1977 Jul 20;154(2):185-9. doi: 10.1007/BF00330835.
When arsenate-resistant mutants are selected approximately 50 per cent of them are also consitutive for the synthesis of alkaline phosphatase and the Pi-binding protein. Some of these mutants are linked to ilv (phoS- or phoT-), other are linked to proC (phoR-). One of the mutant strains linked to ilv lost the Pi-binding protein (the phoS gene product). Resistance to arsenate, constitutivty for alkaline phosphatase synthesis and loss of the Pi-binding protein occurred pleiotropically by the same phoS- mutation.
当选择抗砷酸盐突变体时，其中约50%的突变体同时也组成型合成碱性磷酸酶和磷酸结合蛋白。其中一些突变体与ilv（phoS-或phoT-）连锁，其他的则与proC（phoR-）连锁。一个与ilv连锁的突变菌株失去了磷酸结合蛋白（phoS基因产物）。对砷酸盐的抗性、碱性磷酸酶合成的组成型以及磷酸结合蛋白的缺失是由相同的phoS-突变多效性地发生的。
