Department of Dermatology, Universitair Ziekenhuis Brussel (UZB), Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090, Jette, Belgium.
Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Arch Dermatol Res. 2021 Oct;313(8):669-677. doi: 10.1007/s00403-020-02148-0. Epub 2020 Oct 27.
Prurigo nodularis (PN) is a chronic, pruritic, debilitating disease. Previous studies found that chronic pruritus in general negatively affects patients' quality of life (QoL). However, results about the impact of PN on QoL are conflicting. Our objective was to assess the QoL burden of PN. A systematic review was conducted of all published studies that assessed QoL measures in PN. OVID MEDLINE, EMBASE, SCOPUS, and Web of Science were searched. Pooled meta-analysis (means) was performed using random-effects weighting. Overall, 13 studies met inclusion criteria. All studies identified QoL reductions in patients suffering from PN compared to control groups. The most common QoL instrument used was the Dermatology Life Quality Index [n = 9 studies; pooled mean (95% confidence interval): 13.8 (10.6-16.9), denoting a very large effect]. In particular, PN was associated with substantial impact on multiple domains of QoL. No publication bias was detected. In conclusion, QoL is negatively impacted in PN. Future studies are necessary to determine the best instruments of measuring QoL in PN patients, better understand this association, and assess the impact in males and females separately. PROSPERO CRD42019136193.
结节性痒疹（PN）是一种慢性、瘙痒、使人虚弱的疾病。先前的研究发现，一般来说，慢性瘙痒会对患者的生活质量（QoL）产生负面影响。然而，关于 PN 对 QoL 的影响的结果存在矛盾。我们的目的是评估 PN 的 QoL 负担。对所有评估 PN 中 QoL 措施的已发表研究进行了系统回顾。检索了 OVID MEDLINE、EMBASE、SCOPUS 和 Web of Science。使用随机效应加权进行了汇总荟萃分析（平均值）。总体而言，有 13 项研究符合纳入标准。所有研究都发现与对照组相比，患有 PN 的患者的 QoL 降低。使用最常见的 QoL 工具是皮肤病生活质量指数[9 项研究；汇总平均值（95%置信区间）：13.8（10.6-16.9），表示非常大的影响]。特别是，PN 与多个 QoL 领域的重大影响有关。未发现发表偏倚。总之，PN 会对 QoL 产生负面影响。需要进一步研究以确定衡量 PN 患者 QoL 的最佳工具，更好地理解这种关联，并分别评估男性和女性的影响。PROSPERO CRD42019136193。
