Department of Pharmacology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun - 248001, Uttarakhand, India.
Department of Biochemistry, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun - 248001, Uttarakhand, India.
Curr Drug Targets. 2021;22(7):816-822. doi: 10.2174/1389450121666201027124947.
Postmenopausal osteoporosis (PMO) is characterized by low bone mass and structural deterioration of bone tissue with increased risk of fracture in postmenopausal women. It is due to the deficiency of estrogen production after menopause, which causes the imbalance in the bone remodeling process where resorption/formation skewed more towards resoption, which leads to bone loss. It causes high morbidity and severe health complication among the affected women. The current PMO therapy has many unwanted side effects and even increases the possibility of tumorigenesis. Therefore, an alternative therapy that is safe and effective is required. Probiotics are dietary supplements consisting of beneficial microbes and when administered in an adequate amount, confer a health benefit to the host. Recent scientific evidences suggested the link between the intestinal microbiota and bone health. This review discusses the process of bone remodeling and the role of intestinal microbiota on the bone metabolism of the host. Further, it summarizes the recent studies of probiotic on an animal model of PMO and also in post postmenopausal women.
绝经后骨质疏松症 (PMO) 的特征是骨量低和骨组织结构恶化，绝经后妇女骨折风险增加。这是由于绝经后雌激素产生不足，导致骨重塑过程中的平衡失衡，吸收/形成向吸收倾斜，导致骨质流失。它会导致受影响的女性发病率高和严重的健康并发症。目前的 PMO 治疗有许多不良副作用，甚至增加了致癌的可能性。因此，需要一种安全有效的替代疗法。益生菌是由有益微生物组成的膳食补充剂，当以足够的量给予时，会给宿主带来健康益处。最近的科学证据表明了肠道微生物群与骨骼健康之间的联系。本综述讨论了骨重塑的过程和肠道微生物群对宿主骨代谢的作用。此外，还总结了最近关于 PMO 动物模型和绝经后妇女中益生菌的研究。
