Russo Marina, Lepre Caterina Claudia, Itro Annalisa, Martin Gabriele, Conza Gianluca, Trotta Maria Consiglia, Puticiu Monica, Hermenean Anca, Gimigliano Francesca, D'Amico Michele, Toro Giuseppe
PhD Course in National Interest in Public Administration and Innovation for Disability and Social Inclusion, Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
School of Pharmacology and Clinical Toxicology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Int J Mol Sci. 2025 Jul 4;26(13):6473. doi: 10.3390/ijms26136473.
Osteoporosis (OP) is a chronic disease characterized by reduced bone mass and altered microarchitecture, leading to bone fragility and fractures. Due to its high morbidity, disability, and healthcare costs, identifying new biomarkers and therapeutic strategies is crucial for improving OP diagnosis and prevention. In this context, this narrative review aims to depict the role of carbohydrate-binding proteins Galectins (Gals) in the combined processes of inflammation and aging contributing to bone fragility by exploring their potential as novel therapeutic targets for OP.
骨质疏松症（OP）是一种以骨量减少和微结构改变为特征的慢性疾病，会导致骨脆性增加和骨折。由于其高发病率、致残率和医疗成本，识别新的生物标志物和治疗策略对于改善OP的诊断和预防至关重要。在此背景下，本叙述性综述旨在通过探索其作为OP新型治疗靶点的潜力，描述碳水化合物结合蛋白半乳糖凝集素（Gals）在导致骨脆性的炎症和衰老联合过程中的作用。
