Department of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ultrasound Med Biol. 2021 Jan;47(1):33-42. doi: 10.1016/j.ultrasmedbio.2020.09.017. Epub 2020 Oct 24.
Global myocardial work (MW) analysis by pressure-strain loops (PSL) allows the non-invasive assessment of left ventricular (LV) function. We aimed to investigate the relationship between LV global MW and the degree of coronary artery stenosis in suspected coronary artery disease (CAD) patients with normal LV ejection fraction and regional wall motion. A total of 164 suspected CAD patients were divided into four groups according to coronary artery angiography. The results showed that global work efficiency (GWE) as the most significant predictor in all MW parameters had the optimal cut-off value of 94.5% for detecting moderate stenosis, and the sensitivity and specificity was 89.7% and 85.8%, respectively. A cut-off value of 94.0% for GWE was the most significant predictor of severe stenosis, and the sensitivity and specificity was 81.4% and 76.1%, respectively. In conclusion, LV global MW is a sensitive tool in detecting the degree of coronary artery stenosis and a potential valuable method to provide early diagnosis for CAD patients.
通过压力-应变环（PSL）进行全球心肌做功（MW）分析可实现对左心室（LV）功能的非侵入性评估。我们旨在研究在 LV 射血分数正常且局部壁运动异常的疑似冠心病（CAD）患者中，LV 整体 MW 与冠状动脉狭窄程度之间的关系。根据冠状动脉造影，将 164 例疑似 CAD 患者分为四组。结果表明，整体工作效率（GWE）作为所有 MW 参数中最显著的预测因子，其检测中度狭窄的最佳截断值为 94.5%，灵敏度和特异性分别为 89.7%和 85.8%。GWE 的 94.0%截断值是严重狭窄的最显著预测因子，灵敏度和特异性分别为 81.4%和 76.1%。总之，LV 整体 MW 是一种检测冠状动脉狭窄程度的敏感工具，也是为 CAD 患者提供早期诊断的潜在有价值的方法。
