PhD student in Public Health, Department of Health, State University of Feira de Santana, Bahia, Brazil.
Department of Health, State University of Feira de Santana.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Dec;130(6):675-680. doi: 10.1016/j.oooo.2020.10.004. Epub 2020 Oct 11.
The objective of this study was to analyze the relationship between psychological factors and salivary flow rate and cortisol levels in individuals with oral lichen planus.
A case-control study of 21 individuals with clinical and histopathological diagnosis of oral lichen planus and 21 individuals without the disease (controls), matched by sex and age, was performed. The Beck Anxiety and Depression Inventories and Perceived Stress Scale were administered, and the salivary flow rate and salivary cortisol secretion pattern were determined. Data were statistically analyzed using Mann-Whitney U, McNemar's χ, and Student's t tests and the Spearman correlation coefficient. The significance level adopted was 5%.
Individuals with oral lichen planus had higher anxiety (P = .001), depression (P = .005), and perceived stress (P = .026) scores, but no association was found between the disease and salivary flow rate (P = .29) or with the pattern of salivary cortisol secretion (at awakening: P = .98; 30 min post-awakening: P = .95; at bedtime: P = .97).
An association was observed between oral lichen planus and anxiety, depression, and stress scores through psychological tests but not in relation to salivary flow rate and the pattern of salivary cortisol secretion.
本研究旨在分析心理因素与口腔扁平苔藓患者唾液流量率和皮质醇水平之间的关系。
对 21 例临床和组织病理学诊断为口腔扁平苔藓的患者（病例组）和 21 例无该疾病的患者（对照组）进行了病例对照研究，匹配了性别和年龄。采用贝克焦虑和抑郁量表和感知压力量表进行评估，并测定唾液流量率和唾液皮质醇分泌模式。采用曼-惠特尼 U 检验、 McNemar χ 检验、学生 t 检验和斯皮尔曼相关系数对数据进行统计学分析。采用 5%的显著性水平。
口腔扁平苔藓患者的焦虑评分（P =.001）、抑郁评分（P =.005）和感知压力评分（P =.026）较高，但疾病与唾液流量率（P =.29）或唾液皮质醇分泌模式之间没有相关性（觉醒时：P =.98；觉醒后 30 分钟：P =.95；睡前：P =.97）。
通过心理测试发现，口腔扁平苔藓与焦虑、抑郁和压力评分之间存在关联，但与唾液流量率和唾液皮质醇分泌模式无关。
