唾液 Α-淀粉酶是否是口腔扁平苔藓患者心理状态和生活质量的可靠指标：一项病例对照研究。

Is Salivary Α-Amylase a Reliable Indicator of Psychological Status and Quality of Life in Patients with Oral Lichen Planus: a Case-Control Study.

机构信息

Dental Clinic Split, Split, Croatia,

Department of Oral Medicine, Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia.

出版信息

Cell Physiol Biochem. 2024 Jul 12;58(4):311-321. doi: 10.33594/000000714.

DOI:10.33594/000000714

PMID:39012386

Abstract

BACKGROUND/AIMS: The objectives of our study were to determine salivary α-amylase activity (stress biomarker) and its association with psychological status and quality of life (QoL), disease duration and intensity of symptoms (pain/burning) in patients with OLP.

METHODS

A total of 50 subjects participated in this case-control study: 30 patients with oral lichen planus (OLP); 20 control subjects. Unstimulated whole saliva (UWS) was collected between 9 and 10 am to avoid diurnal fluctuations. Psychological status was assessed using the Croatian validated version of the original Depression, Anxiety and Stress Scale (DASS-21). The impact of oral health on QoL was assessed using the Croatian version of the Oral Health Impact Profile Questionnaire (OHIP-CRO14).

RESULTS

There was no statistically significant difference in salivary α-amylase activity between patients with OLP (N=30) and control subjects (N=20) (133813.3 vs. 166815.5 U/L, p=0.314; t-test). Depression, anxiety and stress showed no statistically significant difference between patients with OLP and control subjects (p=0.076, p=0.111, p=0.209; t-test). The patients with OLP had statistically significantly poorer QoL (total) compared to control subjects (p=0.004, t-test). There was a moderate positive correlation between symptom intensity (pain/burning) and poor QoL (total) (r=0.584, p<0.001), the OHIP-CRO14 dimension "physical pain" (r=0.661, p<0.001), "psychological impossibility" (r=0.555, p<0.01), "handicap" (r=0.546, p<0.01).

CONCLUSION

Although salivary α-amylase showed no statistically significant difference between patients with OLP and control subjects, the patients with OLP had poorer psychological status (three times higher scores for depression and two times higher scores for anxiety) and poorer QoL compared to the control subjects. Recognising and treating mental disorders in patients with OLP is important in order to break the "vicious circle" and achieve a better QoL in these patients.

摘要

背景/目的：本研究的目的是确定唾液α-淀粉酶活性（应激生物标志物）及其与心理状态和生活质量（QoL）、疾病持续时间和症状强度（疼痛/烧灼感）的相关性，在口腔扁平苔藓（OLP）患者中。

方法

共有 50 名受试者参与了这项病例对照研究：30 名口腔扁平苔藓患者（OLP）；20 名对照受试者。在上午 9 点至 10 点之间采集未刺激的全唾液（UWS），以避免昼夜波动。使用经过克罗地亚验证的原始抑郁、焦虑和压力量表（DASS-21）评估心理状态。使用克罗地亚版口腔健康影响概况问卷（OHIP-CRO14）评估口腔健康对 QoL 的影响。

结果

OLP 患者（N=30）和对照组（N=20）之间的唾液α-淀粉酶活性无统计学差异（133813.3 与 166815.5 U/L，p=0.314；t 检验）。OLP 患者和对照组之间的抑郁、焦虑和压力无统计学差异（p=0.076，p=0.111，p=0.209；t 检验）。与对照组相比，OLP 患者的 QoL（总分）明显较差（p=0.004，t 检验）。症状强度（疼痛/烧灼感）与较差的 QoL（总分）之间存在中度正相关（r=0.584，p<0.001），OHIP-CRO14 维度“身体疼痛”（r=0.661，p<0.001），“心理困难”（r=0.555，p<0.01），“障碍”（r=0.546，p<0.01）。