Simoura Juliana Araújo da Silva, Pires Alessandra Laís Pinho Valente, Alves Lísia Daltro Borges, Arsati Franco, Lima-Arsati Ynara Bosco de Oliveira, Santos Jean Nunes Dos, Freitas Valéria Souza
Department of Health Sciences, Universidade Estadual de Feira de Santana, Bahia, Brazil.
Department of Biological Sciences, Universidade Estadual de Feira de Santana, Bahia, Brazil.
Oral Dis. 2023 Apr;29(3):1242-1249. doi: 10.1111/odi.14081. Epub 2021 Dec 5.
To investigate psychological (anxiety, depression, and stress) and salivary (flow and concentration of α-amylase) profile associated with oral lichen planus.
A case-control preliminary study with oral lichen planus patients and age-gender matched controls was conducted. The participants underwent psychological tests (Beck depression and anxiety inventories and perceived stress scale) and saliva collection to determine the unstimulated salivary flow and α-amylase levels at three moments along the day. The data were analyzed statistically using Mann-Whitney, McNemar chi-square and Friedman tests, and the Spearman correlation coefficient. The significance level adopted was 5%.
A total of 46 case-control pairs were recruited. There was a significant correlation between anxiety, depression, stress, and oral lichen planus, as well as the stress and decline of salivary α-amylase levels. Higher concentrations of this biomarker were found in the case group thirty minutes post-awakening.
The applied psychological tests indicated that factors such as anxiety, depression, and stress were associated with oral lichen planus. Salivary analyses demonstrated a higher concentration of α-amylase thirty minutes post-awakening on individuals with the disease and its decline correlated with stress, suggesting the role of α-amylase as a promising biomarker for future studies.
研究与口腔扁平苔藓相关的心理状态（焦虑、抑郁和压力）及唾液情况（唾液流量和α-淀粉酶浓度）。
开展一项病例对照初步研究，纳入口腔扁平苔藓患者及年龄和性别匹配的对照。参与者接受心理测试（贝克抑郁和焦虑量表以及感知压力量表）并收集唾液，以测定一天中三个时间点的非刺激性唾液流量和α-淀粉酶水平。数据采用曼-惠特尼检验、麦克内马尔卡方检验和弗里德曼检验以及斯皮尔曼相关系数进行统计学分析。采用的显著性水平为5%。
共招募了46对病例对照。焦虑、抑郁、压力与口腔扁平苔藓之间存在显著相关性，且压力与唾液α-淀粉酶水平下降之间也存在显著相关性。在病例组中，觉醒后30分钟时该生物标志物的浓度更高。
所应用的心理测试表明，焦虑、抑郁和压力等因素与口腔扁平苔藓相关。唾液分析显示，患病个体在觉醒后30分钟时α-淀粉酶浓度更高，且其下降与压力相关，这表明α-淀粉酶有望成为未来研究中的生物标志物。
