Kendler K S, Tsuang M T, Hays P
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Arch Gen Psychiatry. 1987 Oct;44(10):881-90. doi: 10.1001/archpsyc.1987.01800220047008.
We examined the impact of familial factors on age at onset in schizophrenia. Results from a literature review and from new analyses of two family studies and one twin study of schizophrenia support the following hypotheses: (1) no strong or consistent relationship exists between age at onset in schizophrenia and recurrence risk for schizophrenia in relatives; (2) age at onset in schizophrenia is not strongly related to the recurrence risk for other psychiatric disorders in relatives; and (3) in systematically ascertained pairs of affected siblings, the age at onset of schizophrenia is modestly correlated, whereas the correlation in age at onset in concordant monozygotic twin pairs is much higher. These results suggest that (1) from a familial perspective, early- and late-onset adult schizophrenia appear to be the same disorder, and (2) given that an individual will develop schizophrenia, familial factors, which may be genetic, influence the age at onset of the condition.
我们研究了家族因素对精神分裂症发病年龄的影响。一项文献综述以及两项精神分裂症家族研究和一项双生子研究的新分析结果支持以下假设：（1）精神分裂症的发病年龄与亲属患精神分裂症的复发风险之间不存在强烈或一致的关系；（2）精神分裂症的发病年龄与亲属患其他精神障碍的复发风险没有密切关系；（3）在系统确定的患病同胞对中，精神分裂症的发病年龄存在适度相关性，而在同卵双生子对中发病年龄的相关性要高得多。这些结果表明：（1）从家族角度来看，早发型和晚发型成人精神分裂症似乎是同一种疾病；（2）鉴于个体将会患上精神分裂症，可能具有遗传性的家族因素会影响该病的发病年龄。
