Department of Obstetrics and Gynecology, Chung-Ang University School of Medicine, Seoul, Republic of Korea
Department of Obstetrics and Gynecology, Chung-Ang University School of Medicine, Seoul, Republic of Korea.
Anticancer Res. 2020 Nov;40(11):5969-5979. doi: 10.21873/anticanres.14617.
Dickkopf-3 (DKK3), also known as REIC, is a secreted glycoprotein. DKK3 is aberrantly expressed in various types of human malignant tumours. Promoter methylation status, intracellular protein expression, and protein expression in tumour vessels are significantly correlated with clinical prognostic factors, including survival. In malignant cells, DKK3 is involved in the induction of apoptosis, inhibition of invasion, and remodelling of tumour vasculature. These activities are carried out via the regulation of the beta-catenin signalling and c-Jun N-terminal kinase-dependent cellular pathway, both of which are critical for carcinogenesis. This review explores the potential value of DKK3 as a clinical biomarker and a therapeutic candidate in human malignancies.
Dickkopf-3（DKK3），也称为 REIC，是一种分泌型糖蛋白。DKK3 在各种类型的人类恶性肿瘤中异常表达。启动子甲基化状态、细胞内蛋白表达和肿瘤血管中的蛋白表达与临床预后因素（包括生存）显著相关。在恶性细胞中，DKK3 参与诱导细胞凋亡、抑制侵袭和重塑肿瘤血管。这些活性通过调节β-连环蛋白信号和 c-Jun N 末端激酶依赖性细胞途径来实现，这两者对癌症发生都至关重要。本文综述了 DKK3 作为人类恶性肿瘤的临床生物标志物和治疗候选物的潜在价值。
