Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Key Laboratory for Ubiquitous Network and Service Software of Liaoning, School of Software, Dalian University of Technology, Dalian, Liaoning, China.
J Immunother Cancer. 2020 Oct;8(2). doi: 10.1136/jitc-2020-001247.
Checkpoint targets play a key role in tumor-mediated immune escape and therefore are critical for cancer immunotherapy. Unfortunately, there is a lack of bioinformatics resource that compile all the checkpoint targets for translational research and drug discovery in immuno-oncology.
To this end, we developed checkpoint therapeutic target database (CKTTD), the first comprehensive database for immune checkpoint targets (proteins, miRNAs and LncRNAs) and their modulators. A scoring system was adopted to filter more relevant targets with high confidence. In addition, a few biological databases such as Oncomine, Drugbank, miRBase and Lnc2Cancer database were integrated into CKTTD to provide an in-depth information. Moreover, we computed and provided ligand-binding site information for all the targets which may support bench scientists for drug discovery efforts.
In total, CKTTD compiles 105 checkpoint protein targets, 53 modulators (small-molecules and antibody), 30 miRNAs and 18 LncRNAs in cancer immunotherapy with validated experimental evidences curated from 10 649 literatures via an enhanced text-mining system.
In conclusion, the CKTTD may serve as a useful platform for the research of cancer immunotherapy and drug discovery. The CKTTD database is freely available to public at http://www.ckttdb.org/.
检查点靶标在肿瘤介导的免疫逃逸中起着关键作用，因此对癌症免疫治疗至关重要。不幸的是，缺乏生物信息学资源来编译免疫肿瘤学中转译研究和药物发现的所有检查点靶标。
为此，我们开发了检查点治疗靶标数据库（CKTTD），这是第一个用于免疫检查点靶标（蛋白质、miRNA 和 LncRNA）及其调节剂的综合数据库。采用评分系统筛选更相关、可信度更高的靶标。此外，还整合了 Oncomine、Drugbank、miRBase 和 Lnc2Cancer 等几个生物数据库，为 CKTTD 提供更深入的信息。此外，我们计算并提供了所有靶标的配体结合位点信息，这可能支持实验科学家进行药物发现工作。
总共，CKTTD 编译了 105 个检查点蛋白靶标、53 种调节剂（小分子和抗体）、30 个 miRNA 和 18 个 LncRNA 在癌症免疫治疗中，通过增强的文本挖掘系统从 10649 篇文献中验证了实验证据。
总之，CKTTD 可以作为癌症免疫治疗和药物发现研究的有用平台。CKTTD 数据库可在 http://www.ckttdb.org/ 免费供公众使用。
