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Lnc2Cancer v2.0：更新的人类癌症中经过实验验证的长链非编码 RNA 数据库。

Lnc2Cancer v2.0: updated database of experimentally supported long non-coding RNAs in human cancers.

机构信息

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.

Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China.

出版信息

Nucleic Acids Res. 2019 Jan 8;47(D1):D1028-D1033. doi: 10.1093/nar/gky1096.

DOI:10.1093/nar/gky1096
PMID:30407549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6324001/
Abstract

Lnc2Cancer 2.0 (http://www.bio-bigdata.net/lnc2cancer) is an updated database that provides comprehensive experimentally supported associations between lncRNAs and human cancers. In Lnc2Cancer 2.0, we have updated the database with more data and several new features, including (i) exceeding a 4-fold increase over the previous version, recruiting 4989 lncRNA-cancer associations between 1614 lncRNAs and 165 cancer subtypes. (ii) newly adding about 800 experimentally supported circulating, drug-resistant and prognostic-related lncRNAs in various cancers. (iii) appending the regulatory mechanism of lncRNA in cancer, including microRNA (miRNA), transcription factor (TF), variant and methylation regulation. (iv) increasing more than 70 high-throughput experiments (microarray and next-generation sequencing) of lncRNAs in cancers. (v) Scoring the associations between lncRNA and cancer to evaluate the correlations. (vi) updating the annotation information of lncRNAs (version 28) and containing more detailed descriptions for lncRNAs and cancers. Moreover, a newly designed, user-friendly interface was also developed to provide a convenient platform for users. In particular, the functions of browsing data by cancer primary organ, biomarker type and regulatory mechanism, advanced search following several features and filtering the data by LncRNA-Cancer score were enhanced. Lnc2Cancer 2.0 will be a useful resource platform for further understanding the associations between lncRNA and human cancer.

摘要

Lnc2Cancer 2.0（http://www.bio-bigdata.net/lnc2cancer）是一个更新的数据库，提供了广泛的实验支持的 lncRNA 与人类癌症之间的关联。在 Lnc2Cancer 2.0 中，我们更新了数据库，增加了更多的数据和几个新的功能，包括：（i）超过前一版本的 4 倍，招募了 1614 个 lncRNA 和 165 种癌症亚型之间的 4989 个 lncRNA-癌症关联。（ii）新增加了约 800 个在各种癌症中具有实验支持的循环、耐药和预后相关的 lncRNA。（iii）补充了 lncRNA 在癌症中的调控机制，包括 microRNA（miRNA）、转录因子（TF）、变异和甲基化调控。（iv）增加了 70 多个癌症中 lncRNA 的高通量实验（微阵列和下一代测序）。（v）对 lncRNA 与癌症之间的关联进行评分，以评估相关性。（vi）更新了 lncRNA 的注释信息（版本 28），并为 lncRNA 和癌症提供了更详细的描述。此外，还开发了一个新的、用户友好的界面，为用户提供了一个方便的平台。特别是，通过癌症主要器官、生物标志物类型和调控机制浏览数据的功能、根据几个特征进行高级搜索以及根据 lncRNA-癌症评分过滤数据的功能得到了增强。Lnc2Cancer 2.0 将成为进一步了解 lncRNA 与人类癌症之间关联的有用资源平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f1/6324001/ec1af7d62a2f/gky1096fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f1/6324001/8b6c9064085f/gky1096fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f1/6324001/ec1af7d62a2f/gky1096fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f1/6324001/8b6c9064085f/gky1096fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25f1/6324001/ec1af7d62a2f/gky1096fig2.jpg

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