Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Department of Surgery, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Sci Signal. 2020 Oct 27;13(655):eabc0635. doi: 10.1126/scisignal.abc0635.
Angiomotins are a family of molecular scaffolding proteins that function to organize contact points (called tight junctions in vertebrates) between adjacent cells. Some angiomotin isoforms bind to the actin cytoskeleton and are part of signaling pathways that influence cell morphology and migration. Others cooperate with components of the Hippo signaling pathway and the associated networks to control organ growth. The 130-kDa isoform, AMOT-p130, has critical roles in neural stem cell differentiation, dendritic patterning, and synaptic maturation-attributes that are essential for normal brain development and are consistent with its association with autism. Here, we review and discuss the evidence that supports a role for AMOT-p130 in neuronal development in the central nervous system.
血管生成素是一类分子支架蛋白，其功能是组织相邻细胞之间的接触点（在脊椎动物中称为紧密连接）。一些血管生成素同工型与肌动蛋白细胞骨架结合，是影响细胞形态和迁移的信号通路的一部分。其他同工型与 Hippo 信号通路及其相关网络的成分合作，以控制器官生长。130kDa 同工型 AMOT-p130 在神经干细胞分化、树突模式形成和突触成熟中具有关键作用，这些作用对于正常大脑发育至关重要，并且与它与自闭症的关联一致。在这里，我们回顾和讨论了支持 AMOT-p130 在中枢神经系统神经元发育中发挥作用的证据。
