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中风后抑郁症患者血清脑源性神经营养因子水平降低：一项系统评价和荟萃分析

Decreased Serum Brain-Derived Neurotrophic Factor in Poststroke Depression: A Systematic Review and Meta-Analysis.

作者信息

Zhang Chunhui, Wang Xuefang, Zhu Qinghua, Mei Yongxia, Zhang Zhenxiang, Xu Hui

机构信息

School of Nursing and Health, Zhengzhou University, Zhengzhou, China.

出版信息

Front Psychiatry. 2022 May 19;13:876557. doi: 10.3389/fpsyt.2022.876557. eCollection 2022.

DOI:10.3389/fpsyt.2022.876557
PMID:35664480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9160429/
Abstract

BACKGROUNDS

There were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. Thus, we conducted this systemic review and meta-analysis to explore the alteration of serum BDNF levels in PSD.

METHODS

This study included articles from the Web of Science and PubMed databases that were published before December 2021. STATA 12.0 software was used to compute the standardized mean difference (SMD) and 95% confidence interval (CI) regarding the comparison of serum BDNF in PSD and stroke patients without PSD.

RESULTS

We collected the mean value and standard deviation (SD) of serum BDNF in PSD and stroke patients without PSD from six studies (PSD: = 268, stroke patients without PSD: = 425). The present meta-analysis showed decreased serum BDNF level in patients with PSD, compared to stroke patients without PSD with a random-effects model (mean value of BDNF level [PSD vs. stroke patients without PSD]: 14.106 vs. 17.995 ng/ml; SMD = -1.578; 95% CI: -2.820, -0.337; = 97.8%, -value for Q test < 0.001).

CONCLUSION

Brain-derived neurotrophic factor may work as a potential biomarker to predict the risk of PSD among stroke survivors. More large-sample clinical trials exploring the alteration of serum BDNF levels in PSD among stroke patients need to be conducted to verify this result.

摘要

背景

在先前的研究中，关于中风后抑郁（PSD）患者与无PSD的中风患者之间脑源性神经营养因子（BDNF）水平的比较结果相互矛盾。因此，我们进行了这项系统评价和荟萃分析，以探讨PSD患者血清BDNF水平的变化。

方法

本研究纳入了2021年12月之前发表在科学网和PubMed数据库中的文章。使用STATA 12.0软件计算PSD患者与无PSD的中风患者血清BDNF比较的标准化平均差（SMD）和95%置信区间（CI）。

结果

我们从六项研究中收集了PSD患者与无PSD的中风患者血清BDNF的平均值和标准差（SD）（PSD组： = 268，无PSD的中风患者组： = 425）。本荟萃分析显示，与无PSD的中风患者相比，PSD患者血清BDNF水平降低，采用随机效应模型（BDNF水平的平均值[PSD组与无PSD的中风患者组]：14.106 vs. 17.995 ng/ml；SMD = -1.578；95% CI：-2.820，-0.337； = 97.8%，Q检验的P值<0.001）。

结论

脑源性神经营养因子可能作为一种潜在的生物标志物来预测中风幸存者发生PSD的风险。需要进行更多大样本临床试验来探讨中风患者中PSD患者血清BDNF水平的变化，以验证这一结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/303e2ad277d0/fpsyt-13-876557-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/b8bc2f337514/fpsyt-13-876557-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/83f52a528c62/fpsyt-13-876557-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/303e2ad277d0/fpsyt-13-876557-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/b8bc2f337514/fpsyt-13-876557-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/83f52a528c62/fpsyt-13-876557-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77e2/9160429/303e2ad277d0/fpsyt-13-876557-g003.jpg

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本文引用的文献

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2
Epigenetic marks and their relationship with BDNF in the brain of suicide victims.自杀者大脑中的表观遗传标记及其与 BDNF 的关系。
PLoS One. 2020 Sep 24;15(9):e0239335. doi: 10.1371/journal.pone.0239335. eCollection 2020.
3
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Aging Dis. 2024 Feb 28;16(1):394-407. doi: 10.14336/AD.2024.0214-1.
4
Effect of sacubitril/valsartan on brain natriuretic peptide level and prognosis of acute cerebral infarction.沙库巴曲缬沙坦对急性脑梗死脑利钠肽水平及预后的影响。
PLoS One. 2023 Sep 21;18(9):e0291754. doi: 10.1371/journal.pone.0291754. eCollection 2023.
5
Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling.卒中后抑郁中的星形胶质细胞：在炎症、神经传递和神经营养因子信号中的作用。
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中风后抑郁：2020年更新综述。
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4
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5
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6
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7
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8
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10
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Mol Neurobiol. 2019 May;56(5):3295-3312. doi: 10.1007/s12035-018-1283-6. Epub 2018 Aug 17.