外用吲哚美辛对银屑病无效。
Lack of effect of topical indomethacin on psoriasis.
作者信息
Green C A, Shuster S
机构信息
Department of Dermatology, University of Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1987 Sep;24(3):381-4. doi: 10.1111/j.1365-2125.1987.tb03184.x.
Abstract
Topical 1% indomethacin had no effect on chronic stable plaque psoriasis in an open controlled study using subjective clinical scores nor in a randomised double-blind inert base controlled study using both subjective and objective measurements of lesional response; nor did it initiate or affect the development of psoriasis after cold injury. Previous studies are reviewed and it is concluded that the evidence does not support the hypothesis which relates psoriasis to eicosanoids produced by lipoxygenase activity.
摘要
在一项使用主观临床评分的开放对照研究中，以及在一项使用皮损反应的主观和客观测量的随机双盲惰性基质对照研究中，外用1%吲哚美辛对慢性稳定斑块状银屑病均无效果；它也不会引发冷损伤后银屑病的发生或影响其发展。本文回顾了既往研究，并得出结论：现有证据不支持将银屑病与脂氧合酶活性产生的类二十烷酸相关联的假说。
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