Santos Israel J M, Leite Gerlânia O, Costa José Galberto M, Alves Romulo R N, Campos Adriana R, Menezes Irwin R A, Freita Francisco Ronaldo V, Nunes Maria Janeth H, Almeida Waltécio O
Laboratory of Zoology, Regional University of Cariri (URCA), Pimenta, 63105-000 Crato, CE, Brazil.
Program of Post-Graduation in Pharmacology, Federal University of Santa Maria, Campus Camobi, 97105-900 Santa Maria, RS, Brazil.
Evid Based Complement Alternat Med. 2015;2015:140247. doi: 10.1155/2015/140247. Epub 2015 Nov 18.
Tropidurus hispidus has been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study evaluated the topical anti-inflammatory activity of Tropidurus hispidus fat in treating ear edema in an animal model. Oil from T. hispidus (OTH) was evaluated on its effect against experimental inflammation in mice. OTH was extracted from body fat located in the ventral region of Tropidurus hispidus using hexane as a solvent. We used the model of mouse ear edema induced by phlogistic agents, croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin, and histamine, applied into the right ears of animals pretreated with acetone (control), dexamethasone, or OTH. OTH inhibited the dermatitis induced by all noxious agents, except capsaicin. This effect may be related to the fatty acids present in OTH.
多刺角蜥在巴西东北部的几个地区被用于传统医学。其药用涉及治疗多种疾病，如疣、喉咙痛、扁桃体炎、水痘、带状疱疹、麻疹、哮喘、酗酒和皮肤癣菌病。本研究评估了多刺角蜥脂肪在动物模型中治疗耳部水肿的局部抗炎活性。对多刺角蜥油（OTH）对小鼠实验性炎症的作用进行了评估。OTH是使用己烷作为溶剂从多刺角蜥腹部区域的体脂中提取的。我们使用了由促炎剂巴豆油（单次和多次涂抹）、花生四烯酸、苯酚、辣椒素和组胺诱导的小鼠耳部水肿模型，将这些促炎剂涂抹于用丙酮预处理（对照组）、地塞米松或OTH处理过的动物的右耳。除辣椒素外，OTH抑制了所有有害剂诱导的皮炎。这种作用可能与OTH中存在的脂肪酸有关。
