Lawrence C M, Shuster S
Br J Dermatol. 1985 Jul;113(1):107-15. doi: 10.1111/j.1365-2133.1985.tb02050.x.
The effect of topical clobetasol propionate and a 1% topical indomethacin gel which could inhibit UV erythema was measured on anthralin inflammation by change in skin-fold thickness and erythema. The time course of the inflammatory oedema and erythema were different, as was their response to the drugs studied. The oedema of anthralin inflammation was completely inhibited by clobetasol propionate but the erythemal response showed a small and non-significant reduction. Indomethacin had no effect on anthralin oedema but produced a small but significant reduction in erythema in the first 24 h after anthralin application. These results suggest that either anthralin inflammation is not due to production of prostenoids, or that if it is, it occurs by other than the classical enzymic pathway.
通过测量皮肤褶皱厚度和红斑的变化，研究了外用丙酸氯倍他索和1%外用吲哚美辛凝胶对蒽林诱发炎症的影响，这两种药物均可抑制紫外线红斑。炎症性水肿和红斑的时间进程不同，它们对所研究药物的反应也不同。丙酸氯倍他索可完全抑制蒽林炎症引起的水肿，但红斑反应仅有小幅降低，且无统计学意义。吲哚美辛对蒽林水肿无影响，但在应用蒽林后的最初24小时内，可使红斑有小幅但显著的降低。这些结果表明，要么蒽林炎症并非由前列腺素生成所致，要么即便如此，其发生途径也并非经典的酶促途径。
