1,8-桉叶素：来源、生物活性及应用综述。
1,8-Cineole: a review of source, biological activities, and application.
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550014, China.
The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.
出版信息
J Asian Nat Prod Res. 2021 Oct;23(10):938-954. doi: 10.1080/10286020.2020.1839432. Epub 2020 Oct 28.
1,8-Cineole (also known as eucalyptol) is mostly extracted from the essential oils of plants, which showed extensively pharmacological properties including anti-inflammatory and antioxidant mainly via the regulation on NF-κB and Nrf2, and was used for the treatment of respiratory diseases and cardiovascular, . Although various administration routes have been used in the application of 1.8-cineole, few formulations have been developed to improve its stability and bioavailability. This review retrospects the researches on the source, biological activities, mechanisms, and application of 1,8-cineole since 2000, which provides a view for the further studies on the application and formulations of 1,8-cineole.
1,8-桉叶素（也称为桉油精）主要从植物的精油中提取，具有广泛的药理活性，包括抗炎和抗氧化作用，主要通过调节 NF-κB 和 Nrf2 来实现，用于治疗呼吸道疾病和心血管疾病等。尽管 1,8-桉叶素已经有多种给药途径用于应用，但很少有制剂被开发出来以提高其稳定性和生物利用度。本综述回顾了 2000 年以来 1,8-桉叶素的来源、生物学活性、作用机制和应用研究，为进一步研究 1,8-桉叶素的应用和制剂提供了一个视角。
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