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伊菲状千腺柳珊瑚：从化学剖析到抗癌、抗氧化、α-淀粉酶及α-糖苷酶活性

Chiliadenus iphionoides: From chemical profiling to anticancer, antioxidant, α-amylase, and α-glycosidase activities.

作者信息

Bsharat Odey, Salama Yousef, Al-Hajj Nisreen, Al-Maharik Nawaf

机构信息

Department of Chemistry, Faculty of Sciences, An-Najah National University, Nablus, Palestine.

An-Najah Center for Cancer and Stem Cell Research, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

出版信息

PLoS One. 2025 Jul 1;20(7):e0327632. doi: 10.1371/journal.pone.0327632. eCollection 2025.

DOI:10.1371/journal.pone.0327632
PMID:40591640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12212542/
Abstract

Recently, essential oils (EOs) have garnered attention for their biological properties as a source of natural compounds with anticancer, antibacterial, and antioxidant effects. Chiliadenus iphionoides (Boiss.& Blanche) Brullo is a fragrant aromatic species indigenous to Palestine and the neighboring countries. It is utilized by the Bedouins for the treatment of many ailments. This study aimed to analyze the chemical composition of essential oil extracted from the desiccated leaves of Chiliadenus iphionoides (Boiss.& Blanche) Brullo and to assess its in vitro antioxidant, anticancer, and α-amylase and lipase inhibitory activities. The EO obtained during hydrodistillation was analyzed using gas chromatography-mass spectrometry to ascertain their chemical composition. GC-MS analysis of the EO from dried Chiliadenus iphionoides (Boiss.& Blanche) Brullo leaves identified 47 compounds, comprising 98.81% of the total oil. The predominant constituents included cresol methyl ether (52.93%), ethyl 2-octynoate (14.36%), epi-α-cadinol (6.56%), 1,8-cineole (4.25%), and 7-epi-α-eudesmol (3.66%). The EO exhibited significant antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with an IC50 value of 19.83 ± 0.99 μg/mL. Nevertheless, it exhibited limited lipase activity and subpar α-amylase activity. Chiliadenus iphionoides (Boiss.& Blanche) Brullo EO exhibited significant cytotoxicity against B16F10 and MCF-7 cancer cell lines, with IC50 values of 8.74 ± 0.11 and 13.68 ± 0.17 μg/mL, respectively. The combination of the anticancer medication Taxol (10 ng) with Chiliadenus iphionoides (Boiss.& Blanche) Brullo EO at concentrations of 25 μg/mL and 50 μg/mL significantly enhanced the inhibitory efficacy of Taxol against MCF-7 and B16F10 cells.

摘要

最近，精油（EOs）因其作为具有抗癌、抗菌和抗氧化作用的天然化合物来源的生物学特性而备受关注。Chiliadenus iphionoides（Boiss.& Blanche）Brullo是一种原产于巴勒斯坦及周边国家的芳香植物。贝都因人用它来治疗多种疾病。本研究旨在分析从Chiliadenus iphionoides（Boiss.& Blanche）Brullo干燥叶片中提取的精油的化学成分，并评估其体外抗氧化、抗癌以及α-淀粉酶和脂肪酶抑制活性。采用气相色谱-质谱联用仪分析水蒸馏过程中获得的精油，以确定其化学成分。对干燥的Chiliadenus iphionoides（Boiss.& Blanche）Brullo叶片精油进行气相色谱-质谱联用分析，鉴定出47种化合物，占总油含量的98.81%。主要成分包括甲酚甲醚（52.93%）、2-辛炔酸乙酯（14.36%）、表-α-杜松醇（6.56%）、1,8-桉叶素（4.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/a1faceaf8a35/pone.0327632.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/5d43c112126b/pone.0327632.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/359cfa362198/pone.0327632.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/0a44c2e9a3b4/pone.0327632.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/6c8ae503b75a/pone.0327632.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/3cfc2abbe621/pone.0327632.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/841219f6daf7/pone.0327632.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/a1faceaf8a35/pone.0327632.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/5d43c112126b/pone.0327632.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/359cfa362198/pone.0327632.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/0a44c2e9a3b4/pone.0327632.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/6c8ae503b75a/pone.0327632.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/3cfc2abbe621/pone.0327632.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/841219f6daf7/pone.0327632.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4692/12212542/a1faceaf8a35/pone.0327632.g007.jpg

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