[Protease activity of the nuclear matrix of rat hepatocytes].
作者信息
Kutsyĭ M P, Malakhova L V, Gaziev A I
出版信息
Biokhimiia. 1987 Aug;52(8):1315-8.
PMID:3311176
Abstract
It was demonstrated that the nuclear matrix of rat liver possesses the protease activity. The specific activity of nuclear matrix proteases exceeds that of intact nuclei 7-fold. The optimum activity of nuclear matrix proteases is observed at pH 8-9. The protease activity of the nuclear matrix is inhibited by p-chloromercuribenzoate, N-ethylmaleimide, EDTA, phenylmethylsulfonyl fluoride. This suggests that thiol, serine and metalloproteases are associated with the nuclear matrix.
摘要
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