Kerkelä Martta, Gyllenberg David, Gissler Mika, Sillanmäki Lauri, Keski-Säntti Markus, Hinkka-Yli-Salomäki Susanna, Filatova Svetlana, Hurtig Tuula, Miettunen Jouko, Sourander Andre, Veijola Juha
Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.
Deparment of Child Psychiatry, INVEST Research Flagship Center, Turku University Hospital, University of Turku, Turku, Finland.
Acta Psychiatr Scand. 2021 Feb;143(2):119-129. doi: 10.1111/acps.13247. Epub 2020 Nov 24.
The aim of this study was to explore changes in the incidences of childhood and early adulthood hospital-treated psychiatric disorders in five large Finnish birth cohorts of individuals born between 1966 and 1997.
The five birth cohorts were as follows: Northern Finland Birth Cohort 1966 (NFBC 1966) and 1986 (NFBC 1986), 1987 Finnish Birth Cohort (FBC 1987) and 1997 (FBC 1997), and Finnish 1981 Birth Cohort Study (FBCS 1981). Incidences of hospital-treated psychiatric disorders in each cohort were calculated separately for males (N = 71,209) and females (N = 65,190). Poisson regression was used to test difference in proportions of psychiatric disorders in wide range of diagnosis classes separately in childhood and adolescence, and early adulthood.
The total incidences of psychiatric disorders in childhood and adolescence among males has increased in the birth cohorts over decades (Incidence Rate Ratio, IRR = 1.04 (1.04-1.05); p < 0.001). Similar result was seen among females (IRR = 1.04 (1.03-1.04); p < 0.001). In early adulthood, there was significant increase among females (IRR = 1.04 (1.03-1.05); p < 0.001), but among males, the change was not significant (IRR = 0.99 (0.99-1.00), p = 0.051).
The main finding was that the cumulative incidence of hospital-treated psychiatric disorders increased over the decades in Finland. The increasing trend in hospital-treated psychiatric disorders in early adulthood was detected in females but not in males. In the youngest cohorts, the cumulative incidence of hospital-treated psychiatric disorders was at the same level in males and females, whereas in oldest cohort, males had higher incidence than females.
本研究旨在探讨1966年至1997年出生的五个芬兰大型出生队列中儿童期和成年早期接受医院治疗的精神疾病发病率的变化。
五个出生队列如下:1966年芬兰北部出生队列(NFBC 1966)和1986年(NFBC 1986)、1987年芬兰出生队列(FBC 1987)和1997年(FBC 1997),以及1981年芬兰出生队列研究(FBCS 1981)。分别计算每个队列中男性(N = 71,209)和女性(N = 65,190)接受医院治疗的精神疾病发病率。采用泊松回归分别检验儿童期、青少年期和成年早期广泛诊断类别中精神疾病比例的差异。
几十年来,出生队列中男性儿童期和青少年期精神疾病的总发病率有所增加(发病率比,IRR = 1.04(1.04 - 1.05);p < 0.001)。女性中也观察到类似结果(IRR = 1.04(1.03 - 1.04);p < 0.001)。在成年早期,女性中有显著增加(IRR = 1.04(1.03 - 1.05);p < 0.001),但男性中变化不显著(IRR = 0.99(0.99 - 1.00),p = 0.051)。
主要发现是,几十年来芬兰接受医院治疗的精神疾病的累积发病率有所增加。成年早期接受医院治疗的精神疾病的上升趋势在女性中被发现,但在男性中未被发现。在最年轻的队列中,接受医院治疗的精神疾病的累积发病率在男性和女性中处于同一水平,而在最老的队列中,男性的发病率高于女性。