Department of Dermatology, Mengücek Gazi Training and Research Hospital, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Department of Dermatology, University of Health Science (HSU) Istanbul Training and Research Hospital, Istanbul, Turkey.
Dermatol Ther. 2020 Nov;33(6):e14465. doi: 10.1111/dth.14465. Epub 2020 Nov 5.
Acquired perforating dermatosis (APD) is a group of a rare dermatological disorder characterized by elimination of dermal connective tissue through epidermis. We aimed to evaluate the characteristics of patients diagnosed with APD and to determine the differences in comorbidities according to subtypes of APD. A retrospective, observational, cross-sectional study was designed. Patients diagnosed with APD between January 2008 and January 2019 were reviewed. Eighty patients were included in the study. 61.2% (n = 49) of the patients were female and 38.8% (n = 31) were male with a mean age of 58.4 ± 12.5 years. 82.5% (n = 66) of the patients were diagnosed with reactive perforating collagenosis (RPC) and 17.5% (n = 14) of perforating folliculitis (PF). The most common concomitant disease was diabetes mellitus (82.5%). 5.0% of the patients had malignancy. The comorbidity rate in RPC group was higher than PF (P < .05). Topical steroid was the most frequently (90.0%) used treatment. Complete response was obtained 55.0% of patients. Exitus was observed in 23.8% (n = 19) of patients in a mean 17.6 ± 25.7 months follow-up period. APD may be associated with many diseases. Comorbidities are more frequent in RPC group. This situation warns us to evaluate patients with RPC in more detail for underlying diseases. High mortality rate related to the underlying systemic diseases suggests being careful in terms of mortality in patients diagnosed with APD.
获得性穿孔性皮肤病（APD）是一组罕见的皮肤科疾病，其特征是真皮结缔组织通过表皮排出。我们旨在评估诊断为 APD 的患者的特征，并根据 APD 的亚型确定合并症的差异。设计了一项回顾性、观察性、横断面研究。回顾性分析了 2008 年 1 月至 2019 年 1 月期间诊断为 APD 的患者。本研究共纳入 80 例患者。其中女性占 61.2%（n=49），男性占 38.8%（n=31），平均年龄为 58.4±12.5 岁。82.5%（n=66）的患者被诊断为反应性穿孔性胶原病（RPC），17.5%（n=14）的患者为穿孔性滤泡炎（PF）。最常见的合并症是糖尿病（82.5%）。5.0%的患者患有恶性肿瘤。RPC 组的合并症发生率高于 PF（P<.05）。最常用的治疗方法是局部皮质类固醇（90.0%）。55.0%的患者获得完全缓解。在平均 17.6±25.7 个月的随访期间，有 23.8%（n=19）的患者死亡。APD 可能与许多疾病有关。RPC 组的合并症更为常见。这种情况提醒我们更详细地评估 RPC 患者的潜在疾病。与潜在系统性疾病相关的高死亡率表明在诊断为 APD 的患者中要注意死亡率。
