能量代谢作为铁死亡的调控因子。
Energy metabolism as a regulator of ferroptosis.
机构信息
The Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine; Institute of Nephrology, Zhejiang University; Key Laboratory of Kidney Disease Prevention and Control Technology , Hangzhou, Zhejiang Province, China.
The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine , Hangzhou, China.
出版信息
Cell Cycle. 2020 Nov;19(22):2960-2962. doi: 10.1080/15384101.2020.1838781. Epub 2020 Oct 28.
Abstract
Ferroptosis is a newly identified form of cell death that is regulated by many metabolic pathways, including iron, lipid and amino acids. Recent two studies reveal that the mitochondria and energy stress could also mediate ferroptosis. Gao et al. report that mitochondria play an essential role in ferroptosis induced by cysteine deprivation. In addition, Lee et al. show that energy stress depressed ferroptosis partly through activation of AMP-activated protein kinase. These findings provide potential therapeutic strategies for treating ferroptosis-related diseases, such as cancer, tissue injury and neurodegenerative diseases.
摘要
铁死亡是一种新发现的细胞死亡形式，受多种代谢途径调控，包括铁、脂质和氨基酸。最近两项研究揭示线粒体和能量应激也可以介导铁死亡。高等人报告称，线粒体在半胱氨酸剥夺诱导的铁死亡中起关键作用。此外，李等人表明能量应激通过激活 AMP 激活的蛋白激酶部分抑制铁死亡。这些发现为治疗铁死亡相关疾病（如癌症、组织损伤和神经退行性疾病）提供了潜在的治疗策略。
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