Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Shanghai Clinical College, Anhui Medical University, Shanghai, People's Republic of China.
Int J Nanomedicine. 2022 Aug 6;17:3497-3507. doi: 10.2147/IJN.S372947. eCollection 2022.
Ferroptosis is an iron-dependent form of regulated cell death (RCD), that is associated with peroxidative damage to cellular membranes. A promising therapeutic method is to target ferroptosis. Nanomaterial-induced ferroptosis attracts enormous attention. Nevertheless, there are still certain shortcomings in ferroptosis, such as inadequate triggered immunogenic cell death to suit clinical demands. Various investigations have indicated that ionizing radiation (IR) can further induce ferroptosis. Consequently, it is a potential strategy for cancer therapy that combines nanomaterials and IR to induce ferroptosis. Initially, we discuss various ferroptosis inducers based on nanomaterials in this review. Furthermore, mechanisms of IR-induced ferroptosis are briefly introduced. Ultimately, we assess the feasibility of combining nanomaterials with IR to induce ferroptosis, paving the way for future research.
铁死亡是一种与细胞内过氧化损伤相关的铁依赖性调节性细胞死亡（RCD）形式。靶向铁死亡是一种很有前途的治疗方法。纳米材料诱导的铁死亡引起了广泛关注。然而，铁死亡仍然存在一些缺点，例如诱导的免疫原性细胞死亡不足，无法满足临床需求。各种研究表明，电离辐射（IR）可以进一步诱导铁死亡。因此，将纳米材料和 IR 相结合诱导铁死亡是一种有潜力的癌症治疗策略。在本文中，我们首先讨论了基于纳米材料的各种铁死亡诱导剂。此外，还简要介绍了 IR 诱导铁死亡的机制。最后，我们评估了将纳米材料与 IR 相结合诱导铁死亡的可行性，为未来的研究奠定了基础。
