通过铜催化烯炔的串联环化反应从二氧化碳直接合成三氟甲基取代的氨基甲酸酯。
Direct Access to Trifluoromethyl-Substituted Carbamates from Carbon Dioxide via Copper-Catalyzed Cascade Cyclization of Enynes.
作者信息
Wang Lu, Qi Chaorong, Cheng Ruixiang, Liu Hongjian, Xiong Wenfang, Jiang Huanfeng
机构信息
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , P. R. China.
State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou 510640 , P. R. China.
出版信息
Org Lett. 2019 Sep 20;21(18):7386-7389. doi: 10.1021/acs.orglett.9b02698. Epub 2019 Aug 29.
A copper-catalyzed cascade cyclization of enynes with Togni's reagent, carbon dioxide, and amines has been successfully developed. The reaction provides a direct and efficient route to a range of trifluoromethyl-substituted carbamates, which are difficult to access using existing methods. Mild reaction conditions, good functional tolerance, and wide substrate scope are the feactures of the protocol.
已成功开发出一种铜催化的烯炔与托格尼试剂、二氧化碳和胺的串联环化反应。该反应为一系列三氟甲基取代的氨基甲酸酯提供了一条直接有效的合成路线，而这些化合物用现有方法很难合成。温和的反应条件、良好的官能团耐受性和广泛的底物范围是该方法的特点。
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