Department of Urology, Tianjin Union Medical Center, Tianjin 300121, China.
Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China.
Future Oncol. 2021 Feb;17(6):663-673. doi: 10.2217/fon-2020-0825. Epub 2020 Oct 28.
To determine the role of lamin B1 (LMNB1) in the progression and metastasis of primary prostate cancer (PC). Two PC cohorts were used to investigate the clinical relationship between expression and tumor progression and metastasis. The qRT-PCR results revealed that expression was markedly increased in patients with aggressive features and was associated with worse prognosis. Logistic regression analyses indicated that expression is an independent risk factor for distant metastasis. Kaplan-Meier analysis showed that increased LMNB1 levels were related to poor disease-free survival in the primary PC cohort. This study reveals that upregulation of is associated with cancer metastasis and poor survival outcomes in primary PC patients.
为了确定核层蛋白 B1（LMNB1）在原发性前列腺癌（PC）进展和转移中的作用。使用两个 PC 队列来研究表达与肿瘤进展和转移之间的临床关系。qRT-PCR 结果显示，在具有侵袭性特征的患者中表达显著增加，并与预后不良相关。逻辑回归分析表明，表达是远处转移的独立危险因素。Kaplan-Meier 分析显示，在原发性 PC 队列中，LMNB1 水平升高与疾病无复发生存不良相关。本研究表明，上调与原发性 PC 患者的癌症转移和不良生存结局相关。
