Lamin B1 promotes tumor progression and metastasis in primary prostate cancer patients.

To determine the role of lamin B1 (LMNB1) in the progression and metastasis of primary prostate cancer (PC). Two PC cohorts were used to investigate the clinical relationship between expression and tumor progression and metastasis. The qRT-PCR results revealed that expression was markedly increased in patients with aggressive features and was associated with worse prognosis. Logistic regression analyses indicated that expression is an independent risk factor for distant metastasis. Kaplan-Meier analysis showed that increased LMNB1 levels were related to poor disease-free survival in the primary PC cohort. This study reveals that upregulation of is associated with cancer metastasis and poor survival outcomes in primary PC patients.