Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, China.
Emergency Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Public Health Genomics. 2020;23(5-6):200-209. doi: 10.1159/000509190. Epub 2020 Oct 28.
Common malignant tumors of the urinary system include renal cell carcinoma, bladder carcinoma, and prostate cancer. The research on the CYP24A1 gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. Therefore, we selected bladder cancer, prostate cancer, and renal cancer as the research objects to explore the influence of CYP24A1 on the genetic susceptibility of urinary system tumors.
rs6068816, rs2296241, rs2762934, and rs1570669 in 529 patients and 523 controls were genotyped via the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of two SNPs with susceptibility of urinary system cancer. Database predicts the expression of the CYP24A1 gene in urinary system cancer.
Individuals with the AG genotype of CYP24A1 rs1570669 has a 28% lower risk of developing urinary system tumors (OR = 0.72, 95% CI: 0.56-1.13, p = 0.016) and has a 31% lower risk of developing renal cancer (OR = 0.69, 95% CI: 0.51-0.92, p = 0.012).
CYP24A1 rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.
泌尿系统常见的恶性肿瘤包括肾细胞癌、膀胱癌和前列腺癌。对于前列腺癌 CYP24A1 基因的研究主要集中在欧美人群，而中国人群的研究较少。因此，我们选择膀胱癌、前列腺癌和肾癌作为研究对象，探讨 CYP24A1 对泌尿系统肿瘤遗传易感性的影响。
通过 Agena MassARRAY 对 529 例患者和 523 例对照者的 rs6068816、rs2296241、rs2762934 和 rs1570669 进行基因分型。采用 logistic 回归分析评估两个 SNP 与泌尿系统癌症易感性的优势比（OR）和 95%置信区间（CI）。数据库预测 CYP24A1 基因在泌尿系统癌症中的表达。
CYP24A1 rs1570669 的 AG 基因型个体发生泌尿系统肿瘤的风险降低 28%（OR=0.72，95%CI：0.56-1.13，p=0.016），发生肾癌的风险降低 31%（OR=0.69，95%CI：0.51-0.92，p=0.012）。
CYP24A1 rs1570669 可能在泌尿系统肿瘤和肾癌的易感性中发挥重要作用。
