Department of Urology, Hainan General Hospital, Affiliated Hainan Hospital of Hainan Medical University, Haikou 570311, Hainan Province, People's Republic of China.
J Genet. 2022;101.
Premature ejaculation (PE) is a common male sexual dysfunction disorder, and is considered to have the genetic predisposition. However, the internal regulation mechanisms is still unclear. Hence, this study intended to explore the effects of genetic polymorphisms of on the risk of PE. This case-control study genotyped three SNPs of (rs2762934, rs1570669 and rs6068816) from 139 PE patients and 372 healthy men using Agena MassARRAY platform. Collected data was then processed in SPSS 18.0. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression analysis to evaluate the associations between polymorphisms and the PE risk. The results suggested that allele A of rs1570669 was significantly associated with the increased PE risk (OR=1.38, 95% CI=1.04-1.84, =0.026). Meanwhile, we also identified rs1570669 as a risk factor of PE under the additive model (OR=1.47, 95% CI=1.02-2.11, =0.039) by comparing the genotypic distributions between cases and controls, and genotype AA of rs1570669 was detected to be significantly related with an increased risk of PE under the codominant model (OR=2.26, 95% CI=1.06-4.83, =0.036). This study is the first to proved that the genetic variants of played essential role in affecting the susceptibility to PE in Chinese Han.
早泄（PE）是一种常见的男性性功能障碍疾病，被认为具有遗传倾向。然而，其内部调节机制尚不清楚。因此，本研究旨在探讨基因多态性对 PE 风险的影响。这项病例对照研究使用 Agena MassARRAY 平台对 139 名 PE 患者和 372 名健康男性的三个 SNP（rs2762934、rs1570669 和 rs6068816）进行了基因分型。收集的数据随后在 SPSS 18.0 中进行处理。采用逻辑回归分析计算比值比（ORs）和 95%置信区间（CIs），以评估多态性与 PE 风险之间的关联。结果表明，rs1570669 的等位基因 A 与 PE 风险增加显著相关（OR=1.38，95%CI=1.04-1.84，=0.026）。同时，我们还发现 rs1570669 在加性模型下是 PE 的一个风险因素（OR=1.47，95%CI=1.02-2.11，=0.039），通过比较病例和对照组之间的基因型分布，并发现 rs1570669 的 AA 基因型在显性模型下与 PE 风险增加显著相关（OR=2.26，95%CI=1.06-4.83，=0.036）。本研究首次证明了 基因变异在影响中国汉族人 PE 易感性方面起着重要作用。
