接受血运重建治疗的缺血性脑卒中患者的中性粒细胞与淋巴细胞比值及症状性出血转化
Neutrophil-to-Lymphocyte Ratio and Symptomatic Hemorrhagic Transformation in Ischemic Stroke Patients Undergoing Revascularization.
作者信息
Świtońska Milena, Piekuś-Słomka Natalia, Słomka Artur, Sokal Paweł, Żekanowska Ewa, Lattanzi Simona
机构信息
Department of Neurosurgery and Neurology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum, 85-168 Bydgoszcz, Poland.
Department of Inorganic and Analytical Chemistry, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum, 85-089 Bydgoszcz, Poland.
出版信息
Brain Sci. 2020 Oct 23;10(11):771. doi: 10.3390/brainsci10110771.
OBJECTIVES
Symptomatic hemorrhagic transformation (sHT) is a life-threatening complication of acute ischemic stroke (AIS). The early identification of the patients at increased risk of sHT can have clinically relevant implications. The aim of this study was to explore the validity and accuracy of the neutrophil-to-lymphocyte ratio (NLR) in predicting sHT in patients with AIS undergoing revascularization.
METHODS
Consecutive patients hospitalized for AIS who underwent intravenous thrombolysis, mechanical thrombectomy or both were identified. The NLR values were estimated at admission. The study endpoint was the occurrence of sHT within 24 h from stroke treatment.
RESULTS
Fifty-one patients with AIS were included, with a median age of 67 (interquartile range, 55-78) years. sHT occurred in 10 (19.6%) patients. Patients who developed sHT had higher NLR at admission. NLR was an independent predictor of sHT and showed good discriminatory power (area under the curve 0.81). In a multivariable analysis, NLR and systolic blood pressure were independently associated with sHT.
CONCLUSIONS
NLR at admission can accurately predict sHT in patients with AIS undergoing revascularization.
目的
症状性出血转化（sHT）是急性缺血性卒中（AIS）的一种危及生命的并发症。早期识别sHT风险增加的患者具有临床意义。本研究的目的是探讨中性粒细胞与淋巴细胞比值（NLR）在预测接受血管再通治疗的AIS患者发生sHT中的有效性和准确性。
方法
纳入因AIS住院并接受静脉溶栓、机械取栓或两者兼有的连续患者。入院时评估NLR值。研究终点是卒中治疗后24小时内发生sHT。
结果
纳入51例AIS患者，中位年龄为67岁（四分位间距，55 - 78岁）。10例（19.6%）患者发生sHT。发生sHT的患者入院时NLR较高。NLR是sHT的独立预测因子，具有良好的鉴别能力（曲线下面积为0.81）。在多变量分析中，NLR和收缩压与sHT独立相关。
结论
入院时的NLR可准确预测接受血管再通治疗的AIS患者发生sHT。
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