Richter C
Laboratory of Biochemistry, Swiss Federal Institute of Technology (ETH), Zürich.
Chem Phys Lipids. 1987 Jul-Sep;44(2-4):175-89. doi: 10.1016/0009-3084(87)90049-1.
This article reviews the biophysical consequences of lipid peroxidation in biological membranes. In the lipid domain, lipid peroxidation (a) causes an increase in the order and "viscosity" of the membrane bilayer, particularly at the depth around acyl-carbon 12, (b) changes the thermotropic phase behaviour, (c) decreases the electrical resistance, and (d) facilitates phospholipid exchange between the two monolayers. Upon lipid peroxidation membrane proteins are crosslinked, and their rotational and lateral mobility is decreased. Studies with microsomal cytochrome P-450 suggest protein aggregation but not the increased lipid order to be the major cause of protein immobilization in peroxidized membranes.
本文综述了生物膜中脂质过氧化的生物物理后果。在脂质区域，脂质过氧化：(a) 导致膜双层的有序性和 “粘度” 增加，特别是在酰基碳12周围的深度；(b) 改变热致相行为；(c) 降低电阻；(d) 促进两个单分子层之间的磷脂交换。脂质过氧化时，膜蛋白会发生交联，其旋转和横向移动性降低。对微粒体细胞色素P-450的研究表明，蛋白质聚集而非脂质有序性增加是过氧化膜中蛋白质固定化的主要原因。
