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1.5特斯拉和3特斯拉磁共振成像下胎儿牙胚可视性的比较

Comparison of the Visibility of Fetal Tooth Buds on 1.5 and 3 Tesla MRI.

作者信息

Kunzendorf Burkhard, Diogo Mariana C, Covini Delfina I, Weber Michael, Gruber Gerlinde M, Zeilhofer Hans-Florian, Berg Britt-Isabelle, Prayer Daniela

机构信息

Hightech-Research-Center of Oral and Cranio-Maxillofacial Surgery, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, Switzerland.

Department of Radiology, Division of Neuro- and Musculoskeletal Radiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

出版信息

J Clin Med. 2020 Oct 26;9(11):3424. doi: 10.3390/jcm9113424.

Abstract

Dental anomalies coincide with genetic disorders, and prenatal identification may contribute to a more accurate diagnosis. The aim of this study was to assess whether fetal Magnet Resonance Imaging (MRI) is suitable to visualize and investigate intrauterine dental development in the upper jaw, and to compare the quality of visibility of tooth buds between 1.5 Tesla (T) and 3T images. MR images of fetuses Gestational Week (GW) 26.71 ± 4.97 from 286 pregnant women with diagnoses unrelated to dental anomalies were assessed by three raters. We compared the visibility between groups and field strengths in five gestational age groups, using chi square and Fisher's exact tests. All ten primary tooth buds were identifiable in 5.4% at GW 18-21, in 75.5% at GW 26-29, and in 90.6% at GW 34+. Before GW 30, more tooth buds were identifiable on 3T images than on 1.5T images. Statistical significance was only reached for identification of incisors ( = 0.047). Therefore, 1.5T and 3T images are viable to visualize tooth buds, particularly after GW 25, and their analysis may serve as diagnostic criterion. MRI tooth bud data might have an impact on various fields of research, such as the maldevelopment of teeth and their causes. Analyzing tooth buds as an additional diagnostic criterion is not time consuming, and could lead to an improvement of syndrome diagnosis.

摘要

牙齿异常与遗传疾病相关,产前识别可能有助于更准确的诊断。本研究的目的是评估胎儿磁共振成像(MRI)是否适合可视化和研究上颌骨的宫内牙齿发育,并比较1.5特斯拉(T)和3T图像之间牙胚的可视质量。由三名评估人员对286名诊断与牙齿异常无关的孕妇中妊娠周数(GW)为26.71±4.97的胎儿的MR图像进行评估。我们使用卡方检验和费舍尔精确检验比较了五个孕龄组中不同组和场强之间的可视性。在妊娠18 - 21周时,所有十个乳牙牙胚在5.4%的胎儿中可识别,在妊娠26 - 29周时为75.5%,在妊娠34周及以上时为90.6%。在妊娠30周之前,3T图像上比1.5T图像上可识别出更多的牙胚。仅在切牙的识别上达到统计学显著性(= 0.047)。因此,1.5T和3T图像对于可视化牙胚是可行的,尤其是在妊娠25周之后,对其分析可作为诊断标准。MRI牙胚数据可能会对牙齿发育异常及其原因等各个研究领域产生影响。将牙胚作为额外的诊断标准进行分析并不耗时,并且可能会改善综合征的诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/821a/7693030/c70481ce289e/jcm-09-03424-g001.jpg

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