Zhang C, Zhu K J, Liu J L, Xu G X, Liu W, Jiang F X, Zheng H F, Quan C
Department of Dermatology and Venerology, Anhui Provincial Hospital, Hefei, Anhui, China,
Arch Dermatol Res. 2015 Jul;307(5):455-9. doi: 10.1007/s00403-015-1549-z. Epub 2015 Feb 18.
Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum levels, skin expression of omentin-1, and omentin-1 gene polymorphism (rs2274907; Val109Asp). Levels of omentin-1 in serum samples from 44 patients with psoriasis and 38 healthy controls were analyzed by enzyme-linked immunosorbent assay. The expressions of omentin-1 were measured by immunohistochemistry in 3 psoriasis affected skins and 3 normal skins. The rs2274907 variant was typed using a SNaPshot assay in 354 cases and 214 controls. We found significantly lower serum levels of omentin-1 in psoriasis patients compared with healthy controls (p < 0.001) with an inverse correlation with the Psoriasis Area and Severity Index (p < 0.01). The comparison of genotype and allele distribution revealed no significant difference in genotype frequency between psoriasis patients and controls. Therefore, omentin-1 may have a role in the pathogenesis of psoriasis and might be a potential biological marker for psoriasis severity.
先前的研究表明，银屑病与超重或肥胖个体有关。网膜素是一种最近发现的脂肪因子，参与慢性炎症过程。本研究评估了网膜素与银屑病之间的关系，重点关注网膜素-1血清水平、网膜素-1的皮肤表达以及网膜素-1基因多态性（rs2274907；Val109Asp）。通过酶联免疫吸附测定法分析了44例银屑病患者和38例健康对照者血清样本中网膜素-1的水平。通过免疫组织化学法检测了3例银屑病受累皮肤和3例正常皮肤中网膜素-1的表达。使用SNaPshot分析法对354例病例和214例对照进行rs2274907变异分型。我们发现，与健康对照相比，银屑病患者血清中网膜素-1水平显著降低（p < 0.001），且与银屑病面积和严重程度指数呈负相关（p < 0.01）。基因型和等位基因分布的比较显示，银屑病患者和对照之间的基因型频率没有显著差异。因此，网膜素-1可能在银屑病的发病机制中起作用，并且可能是银屑病严重程度的潜在生物学标志物。
