用于研究和应用的噬菌体多样性
Phage Diversity for Research and Application.
作者信息
Rohde Christine, Wittmann Johannes
机构信息
Leibniz Institute DSMZ, German Collection of Microorganisms and Cell Cultures GmbH, 38124 Braunschweig, Germany.
出版信息
Antibiotics (Basel). 2020 Oct 26;9(11):734. doi: 10.3390/antibiotics9110734.
Abstract
Bacteriophages (in short, phages) are viruses that specifically recognize and infect bacteria; theyare the most abundant forms of life in the biosphere outnumbering bacteria by an estimated factor ofone order of magnitude [1]. Logically, lytic phages have an enormous potential in human andveterinary medicine as "intelligent antibiotics". In contrast to static antibacterial drugs, phagesself-control their numbers at the locus of bacterial infection as they replicate on the unwantedpathogen and disintegrate into their subunits when the bacterial host is eliminated. [...].
摘要
噬菌体（简称为噬菌体）是一类能够特异性识别并感染细菌的病毒；它们是生物圈中最为丰富的生命形式，其数量估计比细菌多出一个数量级[1]。从逻辑上讲，裂解性噬菌体作为“智能抗生素”在人类医学和兽医学中具有巨大潜力。与静态抗菌药物不同，噬菌体在细菌感染部位自我控制数量，因为它们在有害病原体上复制，并在细菌宿主被清除时分解成亚基。[...]
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