Department of Gynecology of Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Cells. 2020 Oct 26;9(11):2358. doi: 10.3390/cells9112358.
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-related receptors (ERRs). In this review article, we discuss the role of ERβ and GPER-1 as mediators of E2 action in TNBC as well as the function of ERRs as activators and modulators of estrogen signaling in this cancer entity. For this purpose, original research articles on estrogen actions in TNBC were considered, which are listed in the PubMed database. Additionally, we performed meta-analyses of publicly accessible integrated gene expression and survival data to elucidate the association of ERβ, GPER-1, and ERR expression levels in TNBC with survival. Finally, options for endocrine therapy strategies for TNBC were discussed.
三阴性乳腺癌（TNBC）缺乏雌激素受体（ER）α，但雌激素受体 ERβ 和 G 蛋白偶联雌激素受体 1（GPER-1）的表达能够在 TNBC 中引发雌激素反应性。TNBC 中的雌激素信号也可以被组成性激活的雌激素相关受体（ERRs）激活和调节。在这篇综述文章中，我们讨论了 ERβ 和 GPER-1 作为 E2 作用在 TNBC 中的介质的作用，以及 ERRs 作为激活剂和调节剂在这种癌症实体中调节雌激素信号的作用。为此，我们考虑了在 PubMed 数据库中列出的关于 TNBC 中雌激素作用的原始研究文章。此外，我们对公开可用的综合基因表达和生存数据进行了荟萃分析，以阐明 TNBC 中 ERβ、GPER-1 和 ERR 表达水平与生存的关联。最后，讨论了 TNBC 的内分泌治疗策略选择。
