通过苯炔和α-氰基-β-亚甲基酮的串联反应直接组装多取代萘。
Direct Assembly of Polysubstituted Naphthalenes via a Tandem Reaction of Benzynes and α-Cyano-β-methylenones.
机构信息
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang Uygur Autonomous Region 832000, China.
出版信息
J Org Chem. 2020 Nov 6;85(21):14210-14218. doi: 10.1021/acs.joc.0c01975. Epub 2020 Oct 28.
PMID:33115229
Abstract
A mild and transition-metal-free benzannulation reaction for the construction of the naphthalene skeleton has been described. Benzynes react with α-cyano-β-alkylenones through a tandem nucleophilic addition/cyclization/aromatization process to afford polysubstituted naphthalenes in 50-94% yields.
摘要
描述了一种温和且无需过渡金属的苯并环化反应，用于构建萘骨架。苯炔与α-氰基-β-烯酮通过串联亲核加成/环化/芳构化过程反应，以 50-94%的产率得到多取代的萘。
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