驻留于胃肠道的、形态可变化的微器件可延长药物在体内的释放。
Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo.
机构信息
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Sci Adv. 2020 Oct 28;6(44). doi: 10.1126/sciadv.abb4133. Print 2020 Oct.
Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite-inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery.
延长释放胃肠道（GI）腔道给药大大增加了药物给药的便利性，从而提高了治疗方案的依从性。然而，由于内在的 GI 运动清除、器械胃滞留和延长的药物释放持续时间很长，这是极具挑战性的。在这里，我们报告说，受 GI 寄生虫启发的主动机械化学治疗夹具（theragripper）可以通过自主锁定在粘膜组织上，在活体动物的胃肠道中停留 24 小时。我们还观察到，使用 theragripper 介导的模型镇痛药物酮咯酸氨丁三醇的传递，消除半衰期显著增加了六倍。这些结果提供了一流的证据，证明形状变化和自锁定微器件可提高延长药物输送的疗效。
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