Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Drug Discov Ther. 2020 Nov 4;14(5):239-242. doi: 10.5582/ddt.2020.03056. Epub 2020 Oct 29.
Althaea officinalis (AO) is reported to have the ability to activate fibroblasts as well as anti-inflammatory and antioxidative properties. Herein, we investigated the effects of this herbal medicine on wound healing in rat models by using stereological methods. In this experiment, 48 male Wistar rats were divided into four groups randomly (n = 12): the control group with no treatment, the gel-base treated group, 5% and 10% AO-gel treated groups. The treatments were administered every 24 hours. Wound closure rate, volume densities of collagen bundles, hair follicles, and vessels, vessel's length density and mean diameter, and fibroblast populations were estimated. Fibroblast populations, hair follicles, and mean diameter of vessels in the dermis of AO-treated groups were noticeably higher than those of control and base groups. Also, collagen bundles synthesis was significantly higher in the AO10%-treated group compared to the control and base groups. According to our research and previous studies, AO has the potential to be considered as an alternative medicine in wound healing treatment; however, further clinical investigations are suggested.
药用蜀葵（AO）据报道具有激活成纤维细胞以及抗炎和抗氧化的特性。在此，我们通过体视学法研究了这种草药对大鼠模型伤口愈合的影响。在该实验中，将 48 只雄性 Wistar 大鼠随机分为四组（n = 12）：无治疗的对照组、凝胶基处理组、5%和 10% AO-凝胶处理组。每 24 小时进行一次治疗。估计伤口闭合率、胶原束、毛囊和血管的体积密度、血管长度密度和平均直径以及成纤维细胞群体。AO 处理组的成纤维细胞群体、毛囊和真皮中血管的平均直径明显高于对照组和基组。此外，与对照组和基组相比，AO10%-处理组的胶原束合成显著增加。根据我们的研究和以前的研究，AO 有可能被认为是伤口愈合治疗中的替代药物；但是，建议进行进一步的临床研究。
