Ashkani-Esfahani Soheil, Khoshneviszadeh Mahsima, Noorafshan Ali, Miri Ramin, Rafiee Shima, Hemyari Kimia, Kardeh Sina, Koohi Hosseinabadi Omid, Fani Dorna, Faridi Elnaz
Student Research Committee, Shiraz university of Medical Sciences, Shiraz, Iran.
Medicinal and Natural products Chemistry Research Center, Shiraz university of Medical Sciences, Shiraz, Iran.
World J Plast Surg. 2019 Jan;8(1):51-57. doi: 10.29252/wjps.8.1.51..
Previous studies indicated that both and have anti-inflammatory, tissue regeneration, antioxidant, and immune-stimulatory effects. It is assumed that a mixture of these two herbal medicines may provide a potent material in treatment of skin wound injuries. Therefore, in this study we investigated the effects of and mixture in the process of wound healing in rat models according to stereological parameters.
In an experiential study, 36 male Sprague-Dawley rats (200±20 g) were randomly assigned into three groups (n=12): The control group which received no treatment, gel base treated group, and the 5% and 5% mixture gel treated group (PA group). Treatments were done every 24 hrs for 15 days. Wound closure rate, volume densities of the collagen bundles and the vessels, vessel's length density and mean diameter, and fibroblast populations were estimated using stereological methods.
PA treated group showed faster wound closure rate in comparison with control and gel-base groups (<0.05). Numerical density of fibroblasts, volume density of collagen bundles, mean diameter, and volume densities of the vessels in PA group were significantly higher than the control and the gel-base treated groups (<0.05).
We showed that and mixture has the ability to improve wound healing by enhancing fibroblast proliferation, collagen bundle synthesis and re-vascularization in skin injuries.
先前的研究表明，[两种草药名称未给出]均具有抗炎、组织再生、抗氧化和免疫刺激作用。据推测，这两种草药的混合物可能为治疗皮肤伤口损伤提供一种有效的物质。因此，在本研究中，我们根据体视学参数研究了[两种草药名称未给出]混合物在大鼠模型伤口愈合过程中的作用。
在一项实验研究中，将36只雄性Sprague-Dawley大鼠（200±20 g）随机分为三组（n = 12）：未接受治疗的对照组、凝胶基质治疗组和5%[两种草药名称未给出]混合物凝胶治疗组（PA组）。每24小时进行一次治疗，持续15天。使用体视学方法估计伤口闭合率、胶原束和血管的体积密度、血管的长度密度和平均直径以及成纤维细胞数量。
与对照组和凝胶基质组相比，PA治疗组显示出更快的伤口闭合率（<0.05）。PA组中成纤维细胞的数值密度、胶原束的体积密度、平均直径和血管的体积密度均显著高于对照组和凝胶基质治疗组（<0.05）。
我们表明，[两种草药名称未给出]混合物具有通过增强皮肤损伤中成纤维细胞增殖、胶原束合成和再血管化来促进伤口愈合的能力。
