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金属纳米颗粒改变了磁场中维生素 K3 诱导的腺嘌呤电荷转移动力学。

Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field.

机构信息

Department of Physics, Indian Institute of Technology Patna, Patna, India.

Chemical Sciences Division, Saha Institute of Nuclear Physics, Kolkata, India.

出版信息

Sci Rep. 2020 Oct 28;10(1):18454. doi: 10.1038/s41598-020-75262-8.

DOI:10.1038/s41598-020-75262-8
PMID:33116189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7595215/
Abstract

In this article, we highlight the alterations in the photoinduced electron transfer (ET) and hydrogen atom transfer (HAT) pathways between an anti-tumor drug vitamin-K3 (MQ) and a nucleobase adenine (ADN) in the presence of gold (Au) and iron (Fe) nanoparticles (NPs). Inside the confined micellar media, with laser flash photolysis corroborated with an external magnetic field (MF), we have detected the transient geminate radicals of MQ and ADN, photo-generated through ET and HAT. We observe that the presence of AuNP on the MQ-ADN complex (MQ-ADN) assists HAT by limiting the ET channel, on the other hand, FeNP on the MQ-ADN complex (MQ-ADN) mostly favors a facile PET. We hypothesize that through selective interactions of the ADN molecules with AuNP and MQ molecules with FeNP, a preferential HAT and PET process is eased. The enhanced HAT and PET have been confirmed by the escape yields of radical intermediates by time-resolved transient absorption spectroscopy in the presence of MF.

摘要

在本文中，我们强调了在金（Au）和铁（Fe）纳米粒子（NPs）存在下，抗肿瘤药物维生素-K3（MQ）和核碱基腺嘌呤（ADN）之间的光诱导电子转移（ET）和氢原子转移（HAT）途径的变化。在受限的胶束介质中，通过激光闪光光解并结合外加磁场（MF），我们检测到了通过 ET 和 HAT 光生成的 MQ 和 ADN 的瞬态成对自由基。我们观察到，AuNP 存在于 MQ-ADN 复合物（MQ-ADN）上有助于 HAT，限制了 ET 通道，另一方面，FeNP 存在于 MQ-ADN 复合物（MQ-ADN）上主要有利于容易的 PET。我们假设，通过 ADN 分子与 AuNP 的选择性相互作用以及 MQ 分子与 FeNP 的选择性相互作用，促进了 HAT 和 PET 过程。通过在 MF 存在下的时间分辨瞬态吸收光谱，通过自由基中间体的逃逸产率证实了增强的 HAT 和 PET。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/358225ca9fbd/41598_2020_75262_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/51fc6f830c9e/41598_2020_75262_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/ae1230420449/41598_2020_75262_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/b196f83a142c/41598_2020_75262_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/8853e4f6928b/41598_2020_75262_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/9aa1685dc2b2/41598_2020_75262_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/08d80bdf3756/41598_2020_75262_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/358225ca9fbd/41598_2020_75262_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/51fc6f830c9e/41598_2020_75262_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/ae1230420449/41598_2020_75262_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/b196f83a142c/41598_2020_75262_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/8853e4f6928b/41598_2020_75262_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/9aa1685dc2b2/41598_2020_75262_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/08d80bdf3756/41598_2020_75262_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f31e/7595215/358225ca9fbd/41598_2020_75262_Fig6_HTML.jpg

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2
Artificial Photosynthesis at Efficiencies Greatly Exceeding That of Natural Photosynthesis.人工光合作用的效率大大超过自然光合作用。
Acc Chem Res. 2019 Nov 19;52(11):3143-3148. doi: 10.1021/acs.accounts.9b00380. Epub 2019 Oct 8.
3
Photodriven quantum teleportation of an electron spin state in a covalent donor-acceptor-radical system.共价供体-受体-自由基体系中电子自旋态的光驱动量子隐形传态。
Nat Chem. 2019 Nov;11(11):981-986. doi: 10.1038/s41557-019-0332-8. Epub 2019 Sep 23.
4
Plasmon-Driven Catalysis on Molecules and Nanomaterials.分子与纳米材料上的等离激元驱动催化
Acc Chem Res. 2019 Sep 17;52(9):2506-2515. doi: 10.1021/acs.accounts.9b00224. Epub 2019 Aug 19.
5
The Nano-Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions.纳米药物的纳-生物相互作用：理解生化驱动力和氧化还原反应。
Acc Chem Res. 2019 Jun 18;52(6):1507-1518. doi: 10.1021/acs.accounts.9b00126. Epub 2019 May 31.
6
Rational Design of Photosynthesis-Inspired Nanomedicines.基于光合作用的纳米药物的合理设计。
Acc Chem Res. 2019 May 21;52(5):1265-1274. doi: 10.1021/acs.accounts.9b00104. Epub 2019 Apr 25.
7
Photogenerated Spin-Entangled Qubit (Radical) Pairs in DNA Hairpins: Observation of Spin Delocalization and Coherence.光致自旋纠缠量子比特（自由基）对在 DNA 发夹中的产生：自旋离域和相干性的观测。
J Am Chem Soc. 2019 Feb 6;141(5):2152-2160. doi: 10.1021/jacs.8b13155. Epub 2019 Jan 25.
8
Reactions of Quinones-Mechanisms, Structures, and Prospects for Food Research.醌类的反应机制、结构及在食品研究中的前景。
J Agric Food Chem. 2018 Dec 19;66(50):13051-13055. doi: 10.1021/acs.jafc.8b05215. Epub 2018 Dec 4.
9
A Continuum of Proton-Coupled Electron Transfer Reactivity.质子耦合电子转移反应性的连续统。
Acc Chem Res. 2018 Oct 16;51(10):2391-2399. doi: 10.1021/acs.accounts.8b00319. Epub 2018 Sep 20.
10
Covalent Radical Pairs as Spin Qubits: Influence of Rapid Electron Motion between Two Equivalent Sites on Spin Coherence.作为自旋量子比特的共价自由基对：两个等价位点之间快速电子运动对自旋相干性的影响。
J Am Chem Soc. 2018 Oct 10;140(40):13011-13021. doi: 10.1021/jacs.8b08105. Epub 2018 Sep 27.