Wagner L, Stielow J B, de Hoog G S, Bensch K, Schwartze V U, Voigt K, Alastruey-Izquierdo A, Kurzai O, Walther G
German National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Persoonia. 2020 Jun;44:67-97. doi: 10.3767/persoonia.2020.44.03. Epub 2019 Aug 29.
species are common soil fungi but also known as agents of human infections (mucormycosis) and used in food production and biotechnology. is the species that is most frequently isolated from clinical sources. The taxonomy of and its close relatives ( complex - MCC) is still based on morphology and mating behaviour. The aim of the present study was a revised taxonomy of the MCC using a polyphasic approach. Using a set of 100 strains molecular phylogenetic analysis of five markers (ITS, , , , and , introduced here) were performed, combined with phenotypic studies, mating tests and the determination of the maximum growth temperatures. The multi-locus analyses revealed 16 phylogenetic species of which 14 showed distinct phenotypical traits and were recognised as discrete species. Five of these species are introduced as novel taxa: sp. nov., sp. nov., sp. nov., sp. nov., and sp. nov. The former formae of represent one or two separate species. In the MCC, the simple presence of well-shaped zygospores only indicates a close relation of both strains, but not necessarily conspecificity. Seven species of the MCC have been implemented in human infection: , , , and .
这些物种是常见的土壤真菌，但也被认为是人类感染（毛霉病）的病原体，并用于食品生产和生物技术。是最常从临床来源分离出的物种。及其近缘种（复合体 - MCC）的分类仍然基于形态学和交配行为。本研究的目的是使用多相方法对MCC进行修订分类。使用一组100个菌株，对五个标记（ITS、、、、以及此处引入的）进行了分子系统发育分析，并结合了表型研究、交配试验和最高生长温度的测定。多位点分析揭示了16个系统发育种，其中14个表现出不同的表型特征，并被确认为不同的物种。其中五个物种被作为新分类群引入：新种、新种、新种、新种和新种。以前的形态代表一个或两个不同的物种。在MCC中，仅存在形态良好的接合孢子仅表明两个菌株关系密切，但不一定是同种。MCC的七个物种已被证实可导致人类感染：、、、和。
