Pediatric Infectious Diseases, Microbiology Children's National Medical Center.
Pediatric Gastroenterology, Microbiology Children's National Medical Center.
J Pediatric Infect Dis Soc. 2018 May 15;7(2):e55-e57. doi: 10.1093/jpids/pix108.
We report here the isolation of Mucor velutinosus from multiple blood cultures performed on samples from Broviac catheters and culture of a Broviac insertion-site wound sample from a 6-year-old boy with a history of intestinal failure secondary to chronic intestinal pseudo-obstruction, parenteral nutrition, and jejunostomy tube dependence. Examination of a slide from the culture revealed the presence of wide nonseptate hyphae with sporangiophores, columella, and chlamydospores. The fungal isolate was sent to the National Institutes of Health for further evaluation and was identified as Mucor velutinosus by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry and genomic sequencing. The patient was treated successfully with intravenous amphotericin B and prompt removal of his central line. To the best of our knowledge, this is the first case of M velutinosus bloodstream infection in a child without cancer.
我们在此报告一例毛霉病，从一名 6 岁男孩的布罗维导管多次血培养标本中分离出来，该男孩因慢性肠假性梗阻、肠外营养和依赖空肠造口管导致肠衰竭，且导管插入部位伤口有分泌物。对培养物的载玻片检查显示存在宽无隔菌丝，带有孢子囊梗、柄和厚垣孢子。将真菌分离株送到美国国立卫生研究院进行进一步评估，并通过基质辅助激光解吸电离飞行时间质谱和基因组测序鉴定为毛霉。该患者成功接受了静脉注射两性霉素 B 治疗，并迅速拔除了中心静脉导管。据我们所知，这是首例无癌症儿童毛霉血流感染病例。
