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预测口腔白斑患者的预后。

Predicts the Prognosis of Patients with Oral Leukoplakia.

作者信息

Lv Zhongjing, Cong Rong, Li Jiafeng, Cao Kun, Bao Qiang, Li Linlin, Yang Feng, Yuan Jian

机构信息

School of Stomatology, Xuzhou Medical University, Xuzhou City, Jiangsu Province, Mainland China.

Department of Stomatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province, Mainland China.

出版信息

Onco Targets Ther. 2020 Oct 8;13:10013-10023. doi: 10.2147/OTT.S261124. eCollection 2020.

DOI:10.2147/OTT.S261124
PMID:33116586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7549501/
Abstract

BACKGROUND

Oral leukoplakia is the most common oral mucosal disease. A proportion of such cases can progress to oral squamous cell carcinoma (OSCC). The mechanism of oral leukoplakia malignant transformation is still unclear. In this study, we analyzed the expression of parathyroid hormone-like hormone () in oral leukoplakia and the effect on prognosis, so as to find reliable molecular markers that can predict oral leukoplakia malignant transformation.

METHODS

We measured PTHrP which is coded by in oral leukoplakia tissues of 79 cases (30 cases progressed to OSCC and 49 did not) and analyzed the clinical outcomes. Then, expression was reduced using lentivirus-mediated small hairpin RNA (shRNA) interference to determine the biological role of in DOK cells.

RESULTS

PTHrP was found to be highly expressed in 38% of tissues of oral leukoplakia. There was weak or no PTHrP expression in 25 patients, moderate expression in 24 patients, and strong in 30 patients with oral leukoplakia. The expression level was associated with the degree of atypical hyperplasia and poor prognosis. The cell proliferation, invasion, migration, cell cloning, and cell cycle were affected after reducing expression.

CONCLUSION

Our data suggest that either or PTHrP plays a key role in the malignant transformation of oral leukoplakia and might be a reliable biomarker for predicting the carcinogenesis of oral leukoplakia.

摘要

背景

口腔白斑是最常见的口腔黏膜疾病。部分此类病例可进展为口腔鳞状细胞癌（OSCC）。口腔白斑恶变的机制仍不清楚。在本研究中，我们分析了甲状旁腺激素样激素（PTHrP）在口腔白斑中的表达及其对预后的影响，以寻找可预测口腔白斑恶变的可靠分子标志物。

方法

我们检测了79例口腔白斑组织中由PTHrP编码的PTHrP（其中30例进展为OSCC，49例未进展）并分析临床结果。然后，使用慢病毒介导的小发夹RNA（shRNA）干扰降低PTHrP表达，以确定PTHrP在DOK细胞中的生物学作用。

结果

发现38%的口腔白斑组织中PTHrP高表达。25例患者PTHrP表达弱或无表达，24例患者中度表达，30例口腔白斑患者强表达。表达水平与非典型增生程度及预后不良相关。降低PTHrP表达后，细胞增殖、侵袭、迁移、细胞克隆及细胞周期均受到影响。

结论

我们的数据表明，PTHrP或其编码基因在口腔白斑恶变中起关键作用，可能是预测口腔白斑癌变的可靠生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/929c761c7d17/OTT-13-10013-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/49d98e30aed1/OTT-13-10013-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/0dcd10f22cf4/OTT-13-10013-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/227a1e1f49c5/OTT-13-10013-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/929c761c7d17/OTT-13-10013-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/49d98e30aed1/OTT-13-10013-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/0dcd10f22cf4/OTT-13-10013-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/227a1e1f49c5/OTT-13-10013-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baf4/7549501/929c761c7d17/OTT-13-10013-g0004.jpg

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